Evidence map›Paper›PMID 40322266›Full record

ArticleOpen forum infectious diseases2025

Severe Parvovirus B19-Associated Myocarditis in Children in the Post-COVID-19 Era: A Multicenter Observational Cohort Study.

Neal Russell, James Hatcher, Tim Best, Judith Breuer, James Charlesworth, Peter Muir, Barry Vipond, Stephane Paulus, Rohit Saxena, Jacob Simmonds and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Neal RussellDepartment of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
James HatcherDepartment of Microbiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Tim BestDepartment of Microbiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Judith BreuerDepartment of Microbiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
James CharlesworthDepartment of Paediatrics, Oxford, UK.
Peter MuirSouth West Regional Laboratory, UK Health Security Agency, Bristol, UK.
Barry VipondSouth West Regional Laboratory, UK Health Security Agency, Bristol, UK.
Stephane PaulusDepartment of Paediatrics, Oxford, UK.
Rohit SaxenaCardiorespiratory and Critical Care Division, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Jacob SimmondsDepartment of Paediatric Cardiology, Great Ormond Street Hospital for Children, London, UK.
Stefania VergnanoPaediatric Infectious Diseases and Immunology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
Peter DavisPaediatric Intensive Care Unit, Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
Seilesh KadambariDepartment of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study describes a cluster of severe parvovirus B19-associated myocarditis cases in children across England in the context of an increase in circulating virus. Cases were identified across 3 large children's centers. Eight cases presented from 1 January 2019 to 31 December 2023 as compared with 19 from 1 January 2024 to 31 August 2024. Almost all (n = 25, 93%) required intensive care, and 24 (88%) received inotropes and 4 (15%) extracorporeal membrane oxygenation. Myocarditis appears to be temporally associated and a late sequela of parvovirus B19, resulting in high rates of intensive care unit admission. Testing with serology and blood polymerase chain reaction should be part of a syndromic screen for all children with severe myocarditis.

Indexed as

epidemiologymyocarditisparvovirus B19pediatricsurveillance

Identifiers

PMID40322266
PMCPMC12048775

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.