Evidence map›Paper›PMID 40322261›Full record

ArticleCommunications materials2024

Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging.

Kang Yong Loh, Lei S Li, Jingyue Fan, Yi Yiing Goh, Weng Heng Liew, Samuel Davis, Yide Zhang, Kai Li, Jie Liu, Liangliang Liang and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Kang Yong LohInstitute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Lei S LiCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Jingyue FanDepartment of Chemistry, National University of Singapore, Singapore, Singapore.
Yi Yiing GohDepartment of Chemistry, National University of Singapore, Singapore, Singapore.
Weng Heng LiewInstitute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Samuel DavisCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Yide ZhangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Kai LiInstitute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Jie LiuKey Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Nanjing Tech University, Nanjing, China.
Liangliang LiangDepartment of Chemistry, National University of Singapore, Singapore, Singapore.
Minjun FengDivision of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore.
Ming YangInstitute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing, China.
Hang ZhangInstitute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing, China.
Ping'an MaState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Guangxue FengDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.
Zhao MuDivision of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore.
Weibo GaoDivision of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore.
Tze Chien SumDivision of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore.
Bin LiuDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.
Jun LinState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Kui YaoInstitute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Lihong V WangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Xiaogang LiuInstitute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Funding

Deep brain photoacoustic tomography at single-neuron resolution using arrays of photonic emitters and high-frequency ultrasound transducersU01NS099717 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROUKES, MICHAEL L, SHEPARD, KENNETH L · 2016 to 2018
$3.0M
Label-free intraoperative photoacoustic microscopy for rapid diagnosis of tissue biopsies with specimen integrityR01EB028277 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI D'APUZZO, MASSIMO, WANG, LIHONG · 2019 to 2022
$2.6M
NIBIB NIH HHS R01 EB028277NINDS NIH HHS U01 NS099717
6 · The paper itself

Abstract

Photoacoustic tomography offers a powerful tool to visualize biological relevant molecules and understand processes within living systems at high resolution in deep tissue, facilitated by the conversion of incident photons into low-scattering acoustic waves through non-radiative relaxation. Although current endogenous and exogenous photoacoustic contrast agents effectively enable molecular imaging within deep tissues, their broad absorption spectra in the visible to near-infrared (NIR) range limit photoacoustic multiplexed imaging. Here, we exploit the distinct ultrasharp NIR absorption peaks of lanthanides to engineer a series of NIR photoacoustic nanocrystals. This engineering involves precise host and dopant material composition, yielding nanocrystals with sharply peaked photoacoustic absorption spectra (~3.2 nm width) and a ~10-fold enhancement in NIR optical absorption for efficient deep tissue imaging. By combining photoacoustic tomography with these engineered nanocrystals, we demonstrate photoacoustic multiplexed differential imaging with substantially decreased background signals and enhanced precision and contrast.

Identifiers

PMID40322261
PMCPMC12048011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.