Evidence map›Paper›PMID 40322216›Full record

ArticleCancer diagnosis & prognosis

The Potential of the C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index as a Prognostic Biomarker in Colorectal Cancer.

Shunsuke Furukawa, Masatsugu Hiraki, Naoya Kimura, Naohiko Kohya, Masashi Sakai, Akashi Ikubo, Ryuichiro Samejima

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Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

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14citing papers in PubMed, 3 pooled it
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Shunsuke FurukawaDepartment of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Japan.
Masatsugu HirakiDepartment of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Japan.
Naoya KimuraDepartment of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Japan.
Naohiko KohyaDepartment of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Japan.
Masashi SakaiDepartment of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Japan.
Akashi IkuboDepartment of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Japan.
Ryuichiro SamejimaDepartment of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aim: The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is an innovative immunonutritional biomarker calculated from CRP, serum albumin, and lymphocyte count levels. This study aimed to determine the significance of the preoperative CALLY index as a prognostic biomarker in patients with stage II-III colorectal cancer who underwent colorectal surgery. Patients and Methods: This retrospective study included 223 patients who underwent colorectal surgery for stage II-III colorectal cancer. The CALLY index was calculated as follows: (albumin × lymphocyte)/(CRP × 104). The patients were divided into CALLY-high group (n=112) and CALLY-low group (n=111) according to the preoperative CALLY index. The associations between the preoperative CALLY index and recurrence-free survival (RFS) and overall survival (OS) were evaluated. Results: The cutoff value of the CALLY index was 3.41. The Kaplan-Meier survival curves for both RFS and OS in patients with stage II-III colorectal cancer demonstrated worse outcomes in the CALLY-low group than in the CALLY-high group (p=0.062 and p=0.008, respectively). A subgroup analysis of both stage II and stage III showed that patients in the CALLY-low group who did not receive postoperative adjuvant chemotherapy had the worst RFS and OS. Conclusion: The preoperative CALLY index may serve as a prognostic biomarker in patients with colorectal cancer. Additionally, a low CALLY index may indicate a poorer prognosis, particularly in patients who did not receive postoperative adjuvant chemotherapy.

Indexed as

CALLY indexcolorectal cancerrecurrence

Identifiers

PMID40322216
PMCPMC12046663

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.