ArticleBiomedical optics express2025
Variation of optical properties of mouse brain using an optical clearing agent: experimental and simulation approaches.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Computational and experimental investigation of nanoparticle effects on tissue optical properties and optical coherence tomography imaging.Biomedical optics express · 2026Article
- Experimental structural characterization of reflection matrices of scattering media.Biomedical optics express · 2026Article
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Authors and funding
7 authors.
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Abstract
For optical diagnosis and therapy in medicine, tracking changes in tissue refractive index (RI), absorption, and scattering coefficient is important. These characteristics may be measured using a variety of techniques. Examples of simulation and experimentation techniques for determining optical parameters are inverse Monte Carlo (IMC) simulation, integrating sphere spectroscopy (ISS), and diffuse reflectance spectroscopy (DRS). The depth of optical measurements is limited by tissue light attenuation in all methods. Using optical clearing agents (OCAs) is a common method to increase optical depth and reduce light scattering in biological tissues. Thus, optical measurement techniques employing new (OCAs) can potentially achieve greater efficiency than traditional agents. This study aims to measure the optical properties of an unsliced mouse brain in the visible spectrum using an OCA composition to clear the tissue. The mouse brain model is useful for developing neuroimaging techniques and optical monitoring of brain activity. In this study, DRS, ISS, and IMC are used to analyze the changes in the RI, absorption, and scattering coefficients of the unsliced mouse brain. A fluorescence test was additionally conducted to evaluate the efficacy of the introduced OCA in comparison to glycerol. The findings and OCA described in this study may be beneficial in optical neurostimulation and brain disease treatments.
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Registered trials
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