Evidence map›Paper›PMID 40321994›Full record

ArticleBiomedical optics express2025

Post-operative monitoring of tissue perfusion in murine skin flaps using enhanced thermal imaging.

Madeline R Kern, Cobey L McGinnis, Didier Dréau, Susan R Trammell

Abstract read
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madeline R KernUniversity of North Carolina at Charlotte, Physics and Optical Science, 9201 University City Blvd, Charlotte, NC 28223, USA.
Cobey L McGinnisUniversity of North Carolina at Charlotte, Physics and Optical Science, 9201 University City Blvd, Charlotte, NC 28223, USA.
Didier DréauUniversity of North Carolina at Charlotte, Biological Sciences, 9201 University City Blvd, Charlotte, NC 28223, USA.
Susan R TrammellUniversity of North Carolina at Charlotte, Physics and Optical Science, 9201 University City Blvd, Charlotte, NC 28223, USA.ORCID https://orcid.org/0000-0002-4861-3485

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inadequate tissue perfusion is a fundamental cause of early complications following a range of surgeries. We are developing a real-time infrared imaging technique, enhanced thermal imaging (ETI), to detect blood vessels embedded in soft tissue. This study evaluated the potential of ETI to detect capillary growth as an indicator of early wound healing in murine skin flaps. The relationship between vessel density and the thermal signal observed with ETI was explored using MATLAB simulations of a geometrically simplified vascularized tissue model. Simulations showed that increased vessel density corresponded to a greater thermal response at the tissue surface. This trend suggests experimental ETI measurements were related to angiogenesis during wound healing. Studies using a similarly grafted murine model confirmed the presence of angiogenesis with physical vessel counts in fluorescence-labeled frozen sections.

Identifiers

PMID40321994
PMCPMC12047707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.