3-Hydroxy-3-methylglutaryl-CoA reductase variants strongly associated with low-density lipoprotein cholesterol levels and diabetes mellitus risk in a Taiwanese population: A Mendelian randomization study.

Lung-An Hsu, Ming-Sheng Teng, De-Min Duan, Kuan-Hung Yeh, Semon Wu, Yu-Lin Ko

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Article in Tzu chi medical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Lung-An Hsu *The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.

Ming-Sheng Teng *Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

De-Min DuanDivision of Cardiology, Department of Internal Medicine and The Cardiovascular Medical Center, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

Kuan-Hung YehDivision of Cardiology, Department of Internal Medicine and The Cardiovascular Medical Center, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

Semon WuDepartment of Life Science, Chinese Culture University, Taipei, Taiwan.

Yu-Lin KoDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a rate-limiting enzyme involved in cholesterol synthesis. The common Materials and Methods: Genome-wide genotyping of 108,880 participants from Taiwan Biobank was used for the association studies and Mendelian randomization (MR) analysis. Results: Regional association and stepwise linear regression analyses showed Conclusion: The

Indexed as

3-Hydroxy-3-methylglutaryl-CoA reductaseDiabetes mellitusLow-density lipoprotein cholesterolMendelian randomizationNonsynonymous mutation

Identifiers

PMID40321961

DOI10.4103/tcmj.tcmj_247_24

PMCPMC12048127

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.