Evidence map›Paper›PMID 40321909›Full record

ReviewIranian journal of public health2025

Comparing the Effects of Glucose-Fructose versus Glucose on the Oxidation Rate: A Systematic Review and Meta-Analysis.

Zahra Gohari Dezfuli, Minoo Hasan Rashedi, Fatemeh Naeini, Sakineh Shab-Bidar, Mohammadhossein Pourgharib-Shahi, Xueying Zhang, Elaheh Dehghani, Kurosh Djafarian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Iranian journal of public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zahra Gohari DezfuliSports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Minoo Hasan RashediSports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh NaeiniDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Sakineh Shab-BidarDepartment of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadhossein Pourgharib-ShahiSports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Xueying ZhangShenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Elaheh DehghaniSports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Kurosh DjafarianSports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Numerous studies have aimed to compare the effects of glucose (Glu) consumption with those of glucose-fructose (Glu-Fru) consumption on oxidation rates during exercise. However, divergent outcomes have surfaced due to variations in exercise protocols and concurrent substance ingestion, leading to a lack of consensus. This systematic review and meta-analysis investigated the comparative effects of Glu and Glu-Fru on total carbohydrate oxidation, endogenous carbohydrate oxidation, exogenous carbohydrate oxidation, and total fat oxidation rates during exercise. Methods: A systematic search of PubMed, Scopus, and Web of Science databases up to February 2023. The search yielded 14 randomized controlled trials involving 125 endurance athletes. Results: The meta-analyses revealed that Glu supplementation significantly increased total carbohydrate oxidation (WMD: 0.21 g/min) compared to Glu-Fru. Endogenous carbohydrate oxidation significantly increased with Glu (WMD: -0.12), while Glu-Fru led to increased exogenous carbohydrate oxidation (WMD: 0.27 g/min). Total fat oxidation decreased with Glu-Fru (WMD: -0.06 g/min). Conclusion: By investigating athletic nutrition complexities, our findings shed light on metabolic responses to Glu-Fru versus Glu supplementation. Tailoring hydration strategies, athletes should select an optimal Glu-Fru to Glu ratio for maximal oxidation and enhanced performance. Future research could explore dose-response relationships for optimal metabolic benefits during exercise.

Indexed as

CarbohydrateEndurance exerciseOxidation ratePerformance

Identifiers

PMID40321909
PMCPMC12045866

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.