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ArticleCRSLS : MIS case reports from SLS

Leiomyoma with Bizarre Nuclei and Hereditary Leiomyomatosis and Renal Cell Carcinoma.

Liaisan Uzianbaeva, Salma Moustafa, Tamera Paczos, Emily Suskin, Sara Said-Delgado, Sara Rabin-Havt, Pengfei Wang

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In one paragraph

Article in CRSLS : MIS case reports from SLS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liaisan UzianbaevaDepartment of Obstetrics and Gynecology, BronxCare Health System, Bronx, NY, USA. (Drs. Uzianbaeva, Moustafa, Said-Delgado, and Wang).
Salma MoustafaDepartment of Obstetrics and Gynecology, BronxCare Health System, Bronx, NY, USA. (Drs. Uzianbaeva, Moustafa, Said-Delgado, and Wang).
Tamera PaczosDepartment of Pathology, BronxCare Health System, Bronx, NY, USA. (Dr. Paczos).
Emily SuskinDepartment of Reproductive and Medical Genetics, Montefiore Einstein, Bronx, NY, USA. (Drs. Suskin and Rabin-Havt).
Sara Said-DelgadoDepartment of Obstetrics and Gynecology, BronxCare Health System, Bronx, NY, USA. (Drs. Uzianbaeva, Moustafa, Said-Delgado, and Wang).
Sara Rabin-HavtDepartment of Reproductive and Medical Genetics, Montefiore Einstein, Bronx, NY, USA. (Drs. Suskin and Rabin-Havt).
Pengfei WangDepartment of Obstetrics & Gynecology and Reproductive Science, The Icahn School of Medicine at Mt Sinai, New York, NY, USA. (Dr. Wang).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Leiomyoma with bizarre nuclei (LBN) is a leiomyoma variant that can be associated with fumarate hydratase (FH) deficiency. Germline pathogenic variants in the Case Description: A 22-year-old nulligravida female presented with multiple uterine fibroids, heavy menstrual bleeding and pelvic pain, lasting over two years. The patient subsequently underwent laparoscopic myomectomy. Histological analysis of the leiomyomas indicated the presence of bizarre nuclei. Immunohistochemical studies confirmed FH deficiency, characterized by loss of FH expression and overexpression of S-(2-succino)-cysteine (2SC). Genetic testing revealed a likely pathogenic variant (c. 1176_1181delTGCTGT) in the Discussion: Due to potentially devastating consequence and the occult nature of RCCs, the discovery of LBN should be followed with further investigation for HLRCC.

Indexed as

Carcinoma, Renal CellLeiomyomaLeiomyomatosisNeoplastic Syndromes, HereditarySkin NeoplasmsUterine NeoplasmsFemaleFumarate HydrataseHumansKidney NeoplasmsYoung AdultFumarate HydrataseBizarre nucleiFumarate hydrataseHereditary leiomyomatosis and renal cell carcinoma (HLRCC)Leiomyoma

Identifiers

PMID40321900
PMCPMC12046535

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.