Evidence map›Paper›PMID 40321808›Full record

ArticleInternational journal of nanomedicine2025

A Bi

Zhiyu Zheng, Gareth R Williams, Honghua Guo, Yilu Zheng, Mengting Xiu, Yanyan Zhang, Huan Zhang, Kai Wang, Jindong Xia, Yu Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhiyu ZhengCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, People's Republic of China.
Gareth R WilliamsUCL School of Pharmacy, University College London, London, UK.
Honghua GuoDepartment of Radiology, Songjiang Hospital Affiliated to Shanghai Jiaotong University of Medicine, Shanghai, People's Republic of China.
Yilu ZhengCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, People's Republic of China.
Mengting XiuCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, People's Republic of China.
Yanyan ZhangCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, People's Republic of China.
Huan ZhangInternational Union Laboratory on Acupuncture Based Target Discovery, International Joint Laboratory on Acupuncture Neuro-Immunology, Shanghai Research Institute of Acupuncture and Meridian, Yue Yang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Kai WangExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Jindong XiaDepartment of Radiology, Songjiang Hospital Affiliated to Shanghai Jiaotong University of Medicine, Shanghai, People's Republic of China.
Yu WangInternational Union Laboratory on Acupuncture Based Target Discovery, International Joint Laboratory on Acupuncture Neuro-Immunology, Shanghai Research Institute of Acupuncture and Meridian, Yue Yang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.ORCID 0000-0001-5107-8770
Li-Min ZhuCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, People's Republic of China.ORCID 0000-0003-1580-6851

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Owing to the limitations of single-mode cancer treatments, combination therapies have attracted much attention. However, constructing a platform for combination therapies in a simple and effective way and improving the overall treatment effect remains a challenge. Our aim was to combine sonodynamic therapy, radiotherapy and chemotherapy together and improve therapeutic outcomes within one nanoplatform. Methods: In this work, we sought to exploit the properties of nanoscale heterojunctions to this end. A multifunctional Bi Results: A comprehensive series of in vitro and in vivo assays demonstrated that the nanoparticles were effectively taken up into cancer cells, where they could induce ROS production and cause cell death. In vivo, this led to a marked reduction in tumor volume in a murine 4T1 cancer model. Conclusion: The formulations developed here have significant potential for future investigation and exploration in the treatment of cancer.

Indexed as

BismuthTheranostic NanomedicineTitaniumAnimalsCell Line, TumorCombined Modality TherapyDoxorubicinFemaleHumansIndolesMiceMice, Inbred BALB CNanoparticlesPhotoacoustic TechniquesPolymersUltrasonic TherapyBismuthDoxorubicinIndolespolydopaminePolymersTitaniumtitanium dioxidecombination therapyDNA repair inhibitionradiosensitizationsonodynamic therapy

Identifiers

PMID40321808
PMCPMC12049674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.