Evidence map›Paper›PMID 40321794›Full record

ArticleClinical and experimental vaccine research2025

Study of the effectiveness of combined rabies-tetanus vaccine as compared to individual vaccines.

Sarah Ghazy, Mohammed E Rashed, Amal E Ali, Hamdallah H Zedan

Abstract read
In one paragraph

Article in Clinical and experimental vaccine research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah GhazyBacterial Lab, Central Administration of Biological and Innovative Products and Clinical Studies, Egyptian Drug Authority, Giza, Egypt.ORCID https://orcid.org/0009-0008-1304-4420
Mohammed E RashedLab Evaluation Administration, Central Administration of Biological and Innovative Products and Clinical Studies, Egyptian Drug Authority, Giza, Egypt.ORCID https://orcid.org/0000-0003-2877-9418
Amal E AliDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-0629-9245
Hamdallah H ZedanDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0001-5238-0584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Effective treatment for animal bites is essential, encompassing immediate measures and protocols for rabies and tetanus vaccination. In this study, we evaluated the effectiveness of the administration of individual and combined rabies-tetanus (RT) vaccines in mice as model animals. Materials and Methods: Animal groups were injected with either undiluted Toxovac Results: All tested vaccines were potent except Spurf; tetanus was not potent. Rabies' immunogenicity for all combinations through both routes of administration showed comparable antibody response & non-significant difference (p≥0.05) at days 14 and 28 compared to single rabies injected by 2 IP doses. Tetanus' immunogenicity in combinations was compared with Toxovac Conclusion: The immune response to rabies in combination vaccine injected as a single SC dose was as effective as 2 IP doses of single vaccine. Our results highlight the potential of RT combination vaccine via SC as a cost-effective means to provide protective immunity.

Indexed as

Combination vaccinesImmunogenicity testPotency testRabiesTetanus

Identifiers

PMID40321794
PMCPMC12046091

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.