Evidence map›Paper›PMID 40321760›Full record

ArticleResearch square2025

Newton's cradle-like allosteric mechanism explains regulatory RsmE RNA binding.

Esteban Finol, Fred F Damberger, Miroslav Krepl, Timo Flügel, Priscilla Dietrich, Thomas C T Michaels, Beat Vögeli, Jiří Šponer, Frédéric H-T Allain

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Esteban FinolInstitute for Biochemistry, Department of Biology, ETH Zurich, 8093, Zurich, Switzerland.ORCID 0000-0002-9830-439X
Fred F DambergerInstitute for Biochemistry, Department of Biology, ETH Zurich, 8093, Zurich, Switzerland.ORCID 0000-0002-8457-3409
Miroslav KreplInstitute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, 61200, Brno, Czech Republic.ORCID 0000-0002-9833-4281
Timo FlügelInstitute for Biochemistry, Department of Biology, ETH Zurich, 8093, Zurich, Switzerland.ORCID 0000-0001-6931-5041
Priscilla DietrichInstitute for Biochemistry, Department of Biology, ETH Zurich, 8093, Zurich, Switzerland.
Thomas C T MichaelsInstitute for Biochemistry, Department of Biology, ETH Zurich, 8093, Zurich, Switzerland.ORCID https://orcid.org/0000-0001-6931-5041
Beat VögeliDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-1176-3137
Jiří ŠponerInstitute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, 61200, Brno, Czech Republic.ORCID 0000-0001-6558-6186
Frédéric H-T AllainInstitute for Biochemistry, Department of Biology, ETH Zurich, 8093, Zurich, Switzerland.ORCID 0000-0002-2131-6237

Funding

Dynein-adaptor interaction mechanisms and malfunction at atomic resolutionR01GM130694 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI VOGELI, BEAT ROLF · 2019 to 2022
$1.3M
Molecular recognition by ADAR1 of Z-RNA within transcriptomesR01GM150642 · NIGMS · UNIVERSITY OF HOUSTON · PI Quentin Vicens, Beat Rolf Vogeli · 2023 to 2026
$1.2M
NIGMS NIH HHS R01 GM130694NIGMS NIH HHS R01 GM150642
6 · The paper itself

Abstract

In the bacterial Csr/Rsm system, non-coding RNAs activate mRNA translation by removing homodimeric Csr/Rsm proteins from the ribosome-binding sites of mRNAs. In

Identifiers

PMID40321760
PMCPMC12047976

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.