Evidence map›Paper›PMID 40321759›Full record

ArticleResearch square2025

FocaL mass drug Administration for Plasmodium vivax Malaria Elimination (FLAME): study protocol for an open-label cluster randomized controlled trial in Peru.

Sydney Fine, Astrid Altamirano Quiroz, Veronica Soto Calle, Paulo Manrique, Hugo Rodriguez, Gabriel Carrasco, Jade Benjamin-Chung, Adam Bennett, Sarah Auburn, Ric Price and 7 more

Registry-linked trialAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05690841 (FocaL Mass Drug Administration for Vivax Malaria Elimination), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05690841 phase3recruitingnot on this map

FocaL Mass Drug Administration for Vivax Malaria Elimination (FLAME): a Pragmatic Cluster Randomized Controlled Trial in Peru

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2027Enrolled7,530ConditionsPlasmodium Vivax Malaria, MalariaArmsFocal Mass Drug Administration (fMDA)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Sydney FineUniversity of California San Francisco.ORCID 0000-0003-2700-9489
Astrid Altamirano QuirozUniversidad Peruana Cayetano Heredia.
Veronica Soto CalleUniversidad Peruana Cayetano Heredia.
Paulo ManriqueHarvard University T H Chan School of Public Health.
Hugo RodriguezUniversidad Peruana Cayetano Heredia.
Gabriel CarrascoUniversidad Peruana Cayetano Heredia.
Jade Benjamin-ChungStanford University.
Adam BennettPATH.
Sarah AuburnMenzies School of Health Research: Charles Darwin University.
Ric PriceMenzies School of Health Research: Charles Darwin University.
Bryan GreenhouseUniversity of California San Francisco.
J Kevin BairdEijkman Institute for Molecular Biology.
Gonzalo DomingoPATH.
Michelle RohUniversity of California San Francisco.
Angel RosasUniversidad Peruana Cayetano Heredia.
Alejandro Llanos-CuentasUniversidad Peruana Cayetano Heredia.
Michelle HsiangUniversity of California San Francisco.

Funding

Focal mass drug administration (fMDA) to reduce Plasmodium vivax transmission, a pragmatic cluster randomized controlled trial in PeruU01AI157962 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Michelle Sang Hsiang · 2022 to 2026
$6.3M
Mentoring translational scientists in international infectious disease researchK24AI144048 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bryan R Greenhouse · 2019 to 2026
$1.6M
NIAID NIH HHS K24 AI144048NIAID NIH HHS U01 AI157962
6 · The paper itself

Abstract

Background: Outside of sub-Saharan Africa, Methods: The FocaL mass drug Administration for Discussion: The trial will generate evidence regarding fMDA for Trial registration: Clinicaltrials.gov NCT05690841. This trial was registered on 09 January 2023.

Indexed as

chemopreventioncluster randomized control trialglucose 6 phosphate dehydrogenase deficiencyPeruprimaquinetafenoquine

Identifiers

PMID40321759
PMCPMC12047980

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.