Evidence map›Paper›PMID 40321756›Full record

ArticleResearch square2025

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during

Mebratu A Bitew, Tatiana C Paredes-Santos, Parag Maru, Shruthi Krishnamurthy, Yifan Wang, Lamba O Sangaré, Samuel Duley, Yoshiki Yamaryo-Botté, Cyrille Botte, Jeroen P J Saeij

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Mebratu A BitewDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Tatiana C Paredes-SantosDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Parag MaruDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0001-5607-2677
Shruthi KrishnamurthyDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Yifan WangDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0001-9451-0041
Lamba O SangaréDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Samuel DuleyApicolipid Team & Gemeli Platform, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209, Grenoble, France.
Yoshiki Yamaryo-BottéApicolipid Team & Gemeli Platform, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209, Grenoble, France.
Cyrille BotteApicolipid Team & Gemeli Platform, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209, Grenoble, France.
Jeroen P J SaeijDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0003-0289-7109

Funding

Restriction of Toxoplasma growth in human cellsR01AI173803 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JEROEN SAEIJ · 2024 to 2026
$1.8M
NIAID NIH HHS R01 AI173803
6 · The paper itself

Abstract

Intracellular parasites like

Indexed as

CRISPR screenGRA38host-parasite metabolic interactionslipidomicsmetabolic adaptationphosphatidic acid phosphataseToxoplasma gondii

Identifiers

PMID40321756
PMCPMC12047978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.