Evidence map›Paper›PMID 40321722›Full record

ArticleRadiology case reports2025

Converging pathways of ankylosing spondylitis and rheumatic fever: A unique case.

Rrezarta Alihajdaraj, Xhevdet Krasniqi, Antigona Kabashi Sadikaj, Granit Xhuxha, Vendenis Lahu, Shqipdon Avdiu, Kreshnik Jashari, Jehona Ismaili Kadriaj, Aurora Bakalli

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PubMed Full text at PMC Publisher
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Article in Radiology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Rrezarta AlihajdarajClinic of Rheumatology, University Clinical Center of Kosova, Pristina, Kosovo.
Xhevdet KrasniqiMedical Faculty, University of Prishtina, Pristina, Kosovo.
Antigona Kabashi SadikajClinic of Radiology, University Clinical Center of Kosova, Pristina, Kosovo.
Granit XhuxhaClinic of Cardiology, University Clinical Center of Kosova, Pristina, Kosovo.
Vendenis LahuClinic of Cardiology, University Clinical Center of Kosova, Pristina, Kosovo.
Shqipdon AvdiuClinic of Cardiology, University Clinical Center of Kosova, Pristina, Kosovo.
Kreshnik JashariClinic of Cardiology, University Clinical Center of Kosova, Pristina, Kosovo.
Jehona Ismaili KadriajClinic of Rheumatology, University Clinical Center of Kosova, Pristina, Kosovo.
Aurora BakalliMedical Faculty, University of Prishtina, Pristina, Kosovo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ankylosing spondylitis is a chronic inflammatory disease that belongs to the group of seronegative spondyloarthropathies. Rheumatic fever is an abnormal immune response to group A Streptococcus infections. Severe or recurrent episodes of rheumatic fever can lead to significant morbidity and mortality, often resulting in the development of rheumatic heart disease. We present a unique case of a 50-year-old patient who suffered from rheumatic fever during childhood, which was complicated by mitral stenosis. He underwent surgical mitral valve replacement at the age of 35. At 47, he was diagnosed with ankylosing spondylitis following a 3-year history of worsening symptoms. This is the first case in the medical literature describing a patient with mitral stenosis postrheumatic fever coexisting with ankylosing spondylitis. A microbial infection triggering the autoimmune system in genetically susceptible individuals may be the underlying mechanism. However, further research is needed to fully understand the converging pathways of these 2 diseases.

Indexed as

Ankylosing spondylitisMitral stenosisRheumatic fever

Identifiers

PMID40321722
PMCPMC12049693

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