ArticleNature and science of sleep2025
Bidirectional Communication Between Circadian Rhythm Disruption and Frailty: A Hypothesis From Gut Microbiota Metabolites.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The microbiome-gut-brain axis: a new perspective on the pathogenesis and intervention of frailty.Frontiers in cellular and infection microbiology · 2026Review
- Interpretable Machine Learning for Predicting Cefoperazone-Sulbactam-Associated Coagulation Abnormalities in Elderly Inpatients: A Dual-Center Retrospective Study.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disruption of circadian rhythms and the condition of frailty are believed to be interrelated. Various manifestations of sleep disturbances, including insomnia, disrupted sleep-wake cycles, and alterations in sleep timing, are considered integral components of circadian rhythm disruption, which are also observed in individuals with frailty. Extensive research has established a connection between gut microbiota and both frailty and circadian rhythm disruption. However, prior studies have predominantly focused on investigating isolated links between gut microbiota and its metabolites with either frailty or circadian rhythm disruption, often neglecting the significant role that gut microbiota and its metabolites may play in the bidirectional relationship between circadian rhythms and frailty. Consequently, we propose the hypothesis that circadian rhythm disruption may induce frailty by altering the composition and structure of gut microbiota metabolites, and conversely, frailty may influence circadian rhythm disruption through similar mechanisms. The aim of our hypothesis is to emphasize the important role of gut microbiota metabolites in the bidirectional communication between circadian disruption and frailty and to speculate on the relevant mechanisms by which gut microbiota metabolites mediate the bidirectional communication between circadian disruption and frailty, rather than being solely related to frailty or circadian disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.