Evidence map›Paper›PMID 40321637›Full record

ArticleJournal of surgical case reports2025

Post-operative analgesic regime in a patient with congenital indifference to pain.

Thomas French, Sanjeet Singh Avtaar Singh, Emma Coley, Malcolm Will

Abstract readCase Reports
In one paragraph

Article in Journal of surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thomas FrenchDepartment of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, Little France Crescent, EH16 4SA, Edinburgh, United Kingdom.
Sanjeet Singh Avtaar SinghDepartment of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, Little France Crescent, EH16 4SA, Edinburgh, United Kingdom.
Emma ColeyDepartment of Anaesthesia, Royal Infirmary of Edinburgh, Little France Crescent, EH16 4SA, Edinburgh, United Kingdom.
Malcolm WillDepartment of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, Little France Crescent, EH16 4SA, Edinburgh, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A man in his thirties with congenital indifference to pain with anosmia (CIP) presented to a tertiary centre for an elective biopsy and video-assisted thoracoscopic surgery. Intra-operatively, he demonstrated no autonomic reflex in response to intubation or surgical stimulus, out of keeping with similar case reports in the medical literature. Post-operatively, he developed intermittent tachycardia, hypertension and pyrexia, which was controlled with opioid and non-opioid-based analgesics. Post-operative pyrexia and tachycardia alerted the patient to a developing chest infection, resulting in re-admission. Learning points include the importance of regular and accurate national early warning score documentation in patients with CIP, and the utility of conventional analgesia in tempering the autonomic response to stress in this patient group.

Indexed as

congenital indifference to painmetastasectomysarcomathoracic surgery

Identifiers

PMID40321637
PMCPMC12049192

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.