Evidence map›Paper›PMID 40321617›Full record

ArticleNeuro-oncology advances

Establishment and validation of a nomogram for predicting IDH-wildtype glioblastomas in nonenhancing adult-type diffuse gliomas.

Lei He, Fan Fei, Chengzhi Zhou, Xiaoyan Bai, Shuqing Yu, Lei Wang, Ruxiang Xu, Hanjie Liu

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Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Lei HeDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.ORCID https://orcid.org/0000-0001-8098-2849
Fan FeiDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chengzhi ZhouDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Xiaoyan BaiDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shuqing YuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Lei WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-6916-704X
Ruxiang XuDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Hanjie LiuDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Approximately 8.94%-44.44% of nonenhancing adult-type diffuse gliomas are identified as glioblastomas. Our purpose is to develop a nomogram that can predict glioblastomas from nonenhancing adult-type diffuse gliomas. Methods: Nonenhancing adult-type diffuse gliomas were collected from Beijing Tiantan Hospital and TCIA public database. Univariate and multivariate logistic regression were performed to screen features on the training set. The features with Results: A total of 557 and 67 nonenhancing adult-type diffuse gliomas were collected from Beijing Tiantan Hospital and TCIA, respectively. The T2-FLAIR mismatch sign exhibited 100% specificity but low sensitivity (<30%) in ruling out glioblastoma. Age, tumor location, rADC Conclusions: Positive T2-FLAIR mismatch sign can effectively rule out glioblastoma in nonenhancing adult-type diffuse gliomas with high specificity. Nonenhancing adult-type diffuse gliomas with nomoscore above 138.5 are highly suspicious for glioblastoma or nonglioblastoma with a poor prognosis.

Indexed as

adult-type diffuse gliomaglioblastomanomogramnonenhancingprognosis

Identifiers

PMID40321617
PMCPMC12048881

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