Evidence map›Paper›PMID 40321582›Full record

ArticleACS omega2025

Colorimetric-Electrochemical Combined Method for the Identification of Drugs of Abuse in Blotter Papers: A Powerful Screening Technique Using Three Analytical Responses.

Cláudia Mancilha Rocha, Larissa Magalhães de Almeida Melo, Augusto César Carvalho Santos, João Victor Coelho Pimenta, Glayton Andrade Souza, Luciano Chaves Arantes, Wellington Alves de Barros, Rodinei Augusti, Clésia Cristina Nascentes, Wallans Torres Pio Dos Santos and 1 more

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cláudia Mancilha RochaDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 37270-690, Brazil.
Larissa Magalhães de Almeida MeloDepartamento de Química, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais 39100-000, Brazil.
Augusto César Carvalho SantosDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 37270-690, Brazil.
João Victor Coelho PimentaDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 37270-690, Brazil.
Glayton Andrade SouzaDepartamento de Química, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais 39100-000, Brazil.
Luciano Chaves ArantesLaboratório de Química e Física Forense, Instituto de Criminalística, Polícia Civil do Distrito Federal, Brasília, Distrito Federal 70610-907, Brazil.ORCID https://orcid.org/0000-0003-1705-1974
Wellington Alves de BarrosDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 37270-690, Brazil.
Rodinei AugustiDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 37270-690, Brazil.ORCID https://orcid.org/0000-0002-9448-9518
Clésia Cristina NascentesDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 37270-690, Brazil.
Wallans Torres Pio Dos SantosDepartamento de Farmácia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais 39100-000, Brazil.ORCID https://orcid.org/0000-0001-6585-9930
Ângelo de FátimaDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 37270-690, Brazil.ORCID https://orcid.org/0000-0003-2344-5590

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysergic acid diethylamide (LSD) and phenylethylamine derivatives (NBOHs and NBOMes) are commonly found on seized blotter papers, posing public health risks. Efficient screening methods for identifying these substances are currently limited. To address this, a novel protocol combining colorimetric and electrochemical techniques was developed as a screening method for drugs of abuse in blotter papers. The method uses Emerson's colorimetric reagent (CR) for NBOH identification combined with voltammetric detection via differential pulse stripping adsorptive voltammetry (AdSDPV) using graphite screen-printed electrodes (SPE-Gr). This approach offers, for the first time, an unambiguous identification of NBOHs through three analytical responses: (1) a color change following the addition of the CR; (2) an electrochemical signal indicating the NBOHs' redox process; and (3) a selective electrochemical signal of the colorimetric reaction product (CR-NBOH) on SPE-Gr. It also differentiates NBOH, NBOMes, 2Cs, and LSD, enabling rapid identification of drugs commonly found in blotter papers. Compared to previous sensors, this method provides selective detection of these drugs at the same pH, offering simplicity for forensic applications. The proposed method showed strong electrochemical stability with low variability (<2.3% RSD) and a low detection limit (0.3 μg mL

Identifiers

PMID40321582
PMCPMC12044553

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.