Evidence map›Paper›PMID 40321435›Full record

ArticleClinical pathology (Thousand Oaks, Ventura County, Calif.)

A Case Series Study of Solitary Mucosal Neuroma-Rare Cases of Benign Peripheral Neurogenic Tumours.

Yu Takayama, Satoshi Yokoo, Takahiro Yamaguchi, Keisuke Suzuki, Takahiro Shimizu, Masaru Ogawa, Akinori Gomi, Mai Seki, Takaya Makiguchi

Abstract read
In one paragraph

Article in Clinical pathology (Thousand Oaks, Ventura County, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yu TakayamaDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.ORCID https://orcid.org/0009-0006-3031-0001
Satoshi YokooDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Takahiro YamaguchiDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Keisuke SuzukiDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Takahiro ShimizuDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Masaru OgawaDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Akinori GomiDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Mai SekiDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Takaya MakiguchiDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim/objective: Mucosal neuroma (MN) is a benign peripheral nerve tumour that usually occurs as a symptom of multiple endocrine neoplasia type 2B (MEN2B) (MEN2B-associated MN). MN that is not associated with MEN2B is termed solitary mucosal neuroma (SMN). We present a case of SMN in the upper gingiva and examine previously reported cases. Methods: The study included nine patients (eight from seven articles and one from this study) with SMN. Age of onset, sex, disease duration, tumour site, clinical findings including subjective symptoms, diagnostic method, treatment, prognosis and relationship with MEN2B were investigated in these nine patients. Results and conclusion: SMN is thought to be caused by the overproduction of nerve growth factors due to trauma or chronic continuous stimulation, whereas MEN2B-associated MN is caused by GNDF-induced hyperplasia. Considering the pathogenesis of their development, both diseases exhibit hyperplasia of the nerve fibre bundles and have the same histological type of hypertrophy. MNs (SMN and MEN2B-induced MN) must be differentiated from benign peripheral neurogenic tumours. Morphological recognition and immunohistopathological analyses make this differentiation possible.

Indexed as

benign peripheral neurogenic tumoursimmunohistochemical analysisMucosal neuromas (MN)multiple endocrine neoplasia type 2B (MEN2B)solitary mucosal neuromas (SMN)

Identifiers

PMID40321435
PMCPMC11672371

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.