Evidence map›Paper›PMID 40321406›Full record

ReviewRSC pharmaceutics2025

Biomimetic nanoparticles for targeted therapy of liver disease.

Veena Vijayan, Janitha M Unagolla, Dhruvisha Panchal, Judith Eloyi John, Siddharth S Menon, Jyothi U Menon

Abstract readReview
In one paragraph

Review in RSC pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Nanomedicines in the Treatment of Liver Fibrosis: A Review.International journal of nanomedicine · 2025
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Veena VijayanDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island Kingston RI 02881 USA jmenon@uri.edu.
Janitha M UnagollaDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island Kingston RI 02881 USA jmenon@uri.edu.
Dhruvisha PanchalDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island Kingston RI 02881 USA jmenon@uri.edu.
Judith Eloyi JohnDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island Kingston RI 02881 USA jmenon@uri.edu.
Siddharth S MenonInternational Academy East Troy MI 48083 USA.
Jyothi U MenonDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island Kingston RI 02881 USA jmenon@uri.edu.ORCID https://orcid.org/0000-0002-0762-3513

Funding

Multifunctional Nanoparticle Platform to Prevent Alcohol-Associated HCC DevelopmentR37CA283937 · NCI · UNIVERSITY OF RHODE ISLAND · PI Jyothi Unnikrishna Menon · 2023 to 2026
$1.5M
Nanoparticle-mediated targeting of hepatic macrophages to mitigate inflammation in alcoholic liver diseaseR21AA029750 · NIAAA · UNIVERSITY OF RHODE ISLAND · PI MENON, JYOTHI UNNIKRISHNA · 2022 to 2023
$413k
NCI NIH HHS R37 CA283937NIAAA NIH HHS R21 AA029750
6 · The paper itself

Abstract

Liver fibrosis is a progressive and fatal condition characterized by stiffness and scarring of the liver due to excessive buildup of extracellular matrix (ECM) proteins. If left untreated, it can progress to liver cirrhosis and hepatocellular carcinoma (HCC)-one of the fastest-rising causes of cancer mortality in the United States. Despite the increased prevalence of liver fibrosis due to infections, exposure to toxins, and unhealthy lifestyles, there are no effective treatments available. Recent advances in nanomedicine can lead to more targeted and effective strategies for treating liver diseases than existing treatments. In particular, the use of biomimetic nanoparticles (NPs) such as liposomes and cell-membrane-coated NPs is of interest. NPs functionalized with cell membranes mimic the properties of the source cell used and provide inherent immune evasion ability, homologous adhesion, and prolonged circulation. This review explores the types of biomimetic coatings, different cargoes delivered through biomimetic NPs for various treatment modalities, and the type of core NPs used for targeting liver fibrosis and HCC.

Identifiers

PMID40321406
PMCPMC12045541

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.