ArticleCase reports in perinatal medicine2024
Massive fetal goiter treated by intra-amniotic injection of levothyroxine: a case report.
Article in Case reports in perinatal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Life-threatening fetal goiter: diagnosis and outcomes in four consecutive cases with critical appraisal-why this diagnosis is not obviously trivial.Archives of gynecology and obstetrics · 2026Article
- Tapering Levothyroxine Dose for Intra-Amniotic Infusion in the Antenatal Treatment of Fetal Goiter: A Case Report.Case reports in obstetrics and gynecology · 2025Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objectives: Fetal dyshormonogenetic goiter is a rare condition associated with perinatal complications and sequelae in infants. Although prenatal management remains controversial, further evidence is required for optimal management. Case presentation: A 30-year-old pregnant woman with no history of thyroid disease was referred to our hospital with polyhydramnios. Fetal ultrasonography revealed fetal goiter. Cordocentesis revealed increased thyroid-stimulating hormone (TSH) and low levels of free thyroxine 4 (fT4), which was the basis of diagnosis of fetal hypothyroidism. Intra-amniotic injections of levothyroxine were administered, resulting in a reduction in the goiter size, amount of amniotic fluid, and level of maternal TSH. The mother was euthyroid during pregnancy. The infant was delivered vaginally at full term with a normal thyroid size and no respiratory disorders except hypothyroidism. At 2 years of age, her neurodevelopment is normal. Conclusions: Intra-amniotic injections of levothyroxine for fetal hypothyroidism with massive goiter and polyhydramnios may improve perinatal outcomes.
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