ArticlePlastic and reconstructive surgery. Global open2025
Mortality in Cleft Lip and Palate Patients: A Systematic Review and Meta-analysis.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A Comparative Study of Cleft Management in Different Economic Settings: United States Versus Guatemala.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Prerepair Mortality in Cleft Lip and/or Palate: A Retrospective Analysis of Early Childhood Deaths.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Epidemiological and Clinical Profile of Cleft Lip and/or Palate in Mbujimayi: A Cross-Sectional Study.Health science reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cleft lip and/or palate (CLP) represents one of the most common congenital anomalies among live births globally. Morbidity associated with CLP is well documented in the literature and stratified through measures such as disability-adjusted life years. However, a paucity of literature details mortality rates among different subgroups of patients with CLP. Methods: A meta-analysis was performed using preferred reporting items for systematic reviews and meta-analysis guidelines. Included studies reported on mortality rates of patients with CLP in a liveborn cohort. Studies that reported only intraoperative mortality, included fetal mortality, or included non-CLP conditions in mortality rates were excluded. Meta-analysis was performed through subgroup analysis using random-effects models. Results: Twenty-one studies were included. Mortality rates ranged from 1.22% to 19.8% between studies. Patients with isolated cleft lip had lower odds of mortality compared with CLP (odds ratio [OR] = 0.28 [0.14, 0.56], Conclusions: Mortality rates in patients with CLP are higher for those with an additional comorbidity or younger age (<1 y). Further studies stratifying data by cleft phenotype and age are required to better understand factors that contribute to CLP mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.