Evidence map›Paper›PMID 40321309›Full record

ReviewStructural heart : the journal of the Heart Team2025

Aortic Valve and Left Ventricular Outflow Tract Calcium Distribution and Conduction Outcomes After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.

Princess Neila Litkouhi, Karan Rao, Alexandra Baer, Peter S Hansen, Ravinay Bhindi

Abstract readReview
In one paragraph

Review in Structural heart : the journal of the Heart Team, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Princess Neila LitkouhiDepartment of Cardiology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Karan RaoDepartment of Cardiology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Alexandra BaerDepartment of Cardiology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Peter S HansenDepartment of Cardiology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Ravinay BhindiDepartment of Cardiology, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Permanent pacemaker implantation (PPMI) is an important complication following transcatheter aortic valve replacement (TAVR). The influence of valvular and subvalvular calcium and its distribution between aortic leaflets on the risk of PPMI following TAVR remains unclear. We performed a systematic review of the aortic valve complex (AVC) calcium by leaflet, left ventricular outflow tract (LVOT) calcium by leaflet, total AVC calcium, total LVOT calcium, and mitral annular calcium and its association with post-TAVR atrioventricular block, left bundle branch block, and new PPMI. The search strategy included five databases identifying 893 articles. A total of 34 studies with 11,528 patients were included for qualitative analysis, and seven studies totaling 1056 patients were suitable for quantitative analysis. On meta-analysis, left coronary cusp calcium and right coronary cusp calcium were significant predictors of PPMI, while noncoronary cusp (NCC) calcium was not predictive (left coronary cusp: mean difference: 21.05 mm

Indexed as

CalciumConductionPacemakerRisk stratificationTAVR

Identifiers

PMID40321309
PMCPMC12047526

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.