Evidence map›Paper›PMID 40321300›Full record

ArticleBurns & trauma2025

A bioactive hydrogel patch accelerates revascularization in ischemic lesions for tissue repair.

Zhuo Liu, Kang Wu, Hong Zeng, Wenxin Huang, Xuemeng Wang, Ying Qu, Chuntao Chen, Lei Zhang, Dongpin Sun, Sifeng Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhuo LiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 138 Xueyuan Road, Shanghai 200032, P.R. China.
Kang WuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 138 Xueyuan Road, Shanghai 200032, P.R. China.
Hong ZengDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 138 Xueyuan Road, Shanghai 200032, P.R. China.
Wenxin HuangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 138 Xueyuan Road, Shanghai 200032, P.R. China.
Xuemeng WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 138 Xueyuan Road, Shanghai 200032, P.R. China.
Ying QuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 138 Xueyuan Road, Shanghai 200032, P.R. China.
Chuntao ChenChina Chemicobiology and Functional Materials Institute, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Xuanwu District, Nanjing 210094, P.R. China.
Lei ZhangChina Chemicobiology and Functional Materials Institute, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Xuanwu District, Nanjing 210094, P.R. China.
Dongpin SunChina Chemicobiology and Functional Materials Institute, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Xuanwu District, Nanjing 210094, P.R. China.
Sifeng ChenDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 138 Xueyuan Road, Shanghai 200032, P.R. China.
Xiao LinOrthopedic Institute, Department of Orthopedics, The First Affiliated Hospital, Soochow University, 178 East Ganjiang Road, Gusu District, Suzhou 215021, P.R. China.
Ning SunDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 138 Xueyuan Road, Shanghai 200032, P.R. China.
Lei YangOrthopedic Institute, Department of Orthopedics, The First Affiliated Hospital, Soochow University, 178 East Ganjiang Road, Gusu District, Suzhou 215021, P.R. China.
Chen XuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 138 Xueyuan Road, Shanghai 200032, P.R. China.ORCID https://orcid.org/0000-0001-5146-5260

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Magnesium ions play crucial roles in maintaining cellular functions. Research has shown that Mg Methods: A novel MgAP was developed on the basis of ionic crosslinking. Fourier transform infrared spectroscopy confirmed the chemical structure, whereas rheological analysis demonstrated stable mechanical properties and adaptability to dynamic loads. Sustained Mg Results: Compared with intravenous administration of magnesium chloride, MgAP application effectively improved cardiac function and reduced adverse remodeling in the myocardial infarction rat model. The left ventricular ejection fraction increased by 20.3 ± 6.6%, and the cardiac radial strain improved by 27.4 ± 4.1%. The cardiac fibrosis area and cell apoptosis rate decreased by 10.9 ± 1.2% and 32.1 ± 5.5%, respectively. RNA sequencing analysis also highlighted the upregulation of genes related to cardiac electrophysiological properties, structural and functional intercellular connections, and revascularization. The increased gap junction protein expression and restored local blood supply could contribute to the cardiac repair process posttreatment. The proangiogenic effect of MgAP was also observed in the rat limb ischemia model. Conclusions: The above results revealed the convincing vascular regeneration effect of an ion therapy-based hydrogel, which enabled the local delivery of Mg

Indexed as

Acute myocardial infarctionAngiogenesisIon therapyLower limb ischemia

Identifiers

PMID40321300
PMCPMC12048007

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.