Evidence map›Paper›PMID 40321259›Full record

ArticlemedRxiv : the preprint server for health sciences2025

A Genome-wide Association study of Buccal Mucosa Cancer in India and Multi-ancestry Meta-analysis Identifies Novel Risk Loci and Gene-environment Interactions.

Sharayu Mhatre, Diptavo Dutta, Anand Iyer, Shruti Gholap, Aseem Mishra, Manigreeva Krishnatreya, Grace Sarah George, Pravin Narayanrao Doibale, Yuzheng Dun, Ziqiao Wang and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Sharayu MhatreDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.
Diptavo DuttaIntegrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Anand IyerDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.
Shruti GholapDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.
Aseem MishraDepartment of Head and Neck Surgical Oncology, Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi, Uttar Pradesh, India.
Manigreeva KrishnatreyaDepartment of Cancer Registry and Epidemiology, Dr. Bhubaneswar Borooah Cancer Institute, Tata Memorial Centre, Guwahati, Assam, India.
Grace Sarah GeorgeDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.
Pravin Narayanrao DoibaleDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.
Yuzheng DunDepartment of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Ziqiao WangDepartment of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Om JahagirdarIntegrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Pankaj ChaturvediHomi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India.
Preetha RajaramanRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Cheng-Ping WangNational Taiwan University Hospital, Taipei, Taiwan.
Anil ChaturvediClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Siddhatha KarEarly Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.
Rajesh DikshitDivision of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.
Nilanjan ChatterjeeDepartment of Head and Neck Oncology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.

Funding

Robust Methods for Polygenic Analysis to Inform Disease Etiology and Enhance Risk PredictionR01HG010480 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI CHATTERJEE, NILANJAN · 2019 to 2023
$2.8M
Multifactoral breast cancer risk prediction accounting for ethnic and tumor diversityU01CA249866 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHATTERJEE, NILANJAN · 2020 to 2023
$2.3M
Statistical Methods for Data Integration and Applications to Genome-wide Association StudiesR01HG013137 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI Nilanjan Chatterjee · 2024 to 2026
$843k
Statistical Methods for Data Integration and Applications to Genome-wide Association StudiesR56HG013137 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI CHATTERJEE, NILANJAN · 2023 to 2023
$290k
NCI NIH HHS U01 CA249866NHGRI NIH HHS R01 HG010480NHGRI NIH HHS R01 HG013137NHGRI NIH HHS R56 HG013137
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) of oral cancers (OC) to date have focused predominantly on European Ancestry (EA) populations. India faces an excess burden of OC, but the most common site of occurrence is the cancer of the buccal mucosa, which is relatively rare in EA populations. We conducted a GWAS of buccal mucosa cancer (BMC) comprising 2,160 BMC cases and 2,325 controls from different geographical locations in India. Single-SNP association tests detected one novel locus (6q27) and one novel signal within the known OC risk locus 5p13.33, at the genome-wide significance level (P-value<5 × 10

Identifiers

PMID40321259
PMCPMC12047951

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.