Evidence map›Paper›PMID 40321255›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Lower Odor Identification in Subjective Cognitive Decline: A Meta-analysis.

Benoît Jobin, Coline Zigrand, Johannes Frasnelli, Benjamin Boller, Mark W Albers

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Benoît JobinDepartment of Psychology, Université du Québec à Trois-Rivières, 3351 Boulevard des Forges, Trois-Rivières, QC G9A 5H7, Canada.ORCID 0000-0002-1357-5116
Coline ZigrandDepartment of Psychology, Université du Québec à Montréal, 100 Sherbrooke Street West, Montréal, QC H2X 3P2, Canada.
Johannes FrasnelliResearch Centre of the Institut universitaire de gériatrie de Montréal, CIUSSS du Centre-Sud-de-l'Île-de-Montréal, 4565 Queen Mary Road, Montréal, QC H3W 1W5, Canada.
Benjamin BollerDepartment of Psychology, Université du Québec à Trois-Rivières, 3351 Boulevard des Forges, Trois-Rivières, QC G9A 5H7, Canada.ORCID 0000-0002-6184-1933
Mark W AlbersDepartment of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United States.ORCID 0000-0001-7855-3455

Funding

Digital Accessible Remote Olfactory Mediated Health Assessments forPreclinical ADR42AG062130 · NIA · AROMHA, INC. · PI Sean Reineke · 2021 to 2026
$5.0M
Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2U01DC019579 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI ALBERS, MARK W · 2021 to 2022
$1.3M
NIA NIH HHS R42 AG062130NIDCD NIH HHS U01 DC019579
6 · The paper itself

Abstract

Introduction: Odor identification correlates with Alzheimer's disease (AD) biomarkers, and its decline may emerge before measurable cognitive deficits-as early as the subjective cognitive decline (SCD) stage. We aimed to compare odor identification between SCD and cognitively normal (CN) stages and investigate whether cognitive differences moderate olfactory deficits. Methods: A systematic search of four databases identified studies assessing olfactory identification and cognitive screening in individuals aged 50+. A random-effects meta-analysis was performed on 11 studies (660 SCD, 574 CN). Results: Individuals with SCD exhibited lower olfactory identification scores compared to CN participants (SMD = -0.67, 95%CI [-1.31, -0.03], Discussion: Odor identification is lower in pre-MCI individuals reporting SCD. Olfactory decline may emerge independently prior to measurable cognitive decline, supporting the role of odor identification as a screen for AD.

Indexed as

Alzheimer’s diseaseBiomarkerMeta-AnalysisOlfactionOlfactory identificationSmellSubjective cognitive decline

Identifiers

PMID40321255
PMCPMC12047905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.