Evidence map›Paper›PMID 40321250›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Robert Freercks, Moreno Rodrigues, Kathryn Manning, Jurgen Heymann, Jeffrey B Kopp, Savania Nagiah, Meenakshi Rana, Sander Florman, Rachel Friedman-Moraco, Peter Stock and 21 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Robert FreercksFaculty of Health Sciences, Department of Medicine, Nelson Mandela University, Gqeberha, South Africa.ORCID 0000-0002-7939-1352
Moreno RodriguesDepartment of Medicine, Johns Hopkins University, Baltimore MD, USA.
Kathryn ManningDepartment of Surgery, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4213-2522
Jurgen HeymannDivision of Intramural Research, NIDDK, NIH, Bethesda MD, USA.ORCID 0000-0002-6052-4522
Jeffrey B KoppDivision of Intramural Research, NIDDK, NIH, Bethesda MD, USA.ORCID 0000-0001-9052-186X
Savania NagiahFaculty of Health Sciences, Department of Medicine, Nelson Mandela University, Gqeberha, South Africa.ORCID 0000-0002-7614-8226
Meenakshi RanaDepartment of Surgery, Mount Sinai School of Medicine, New York NY, USA.
Sander FlormanDepartment of Surgery, Mount Sinai School of Medicine, New York NY, USA.ORCID 0000-0002-1635-9136
Rachel Friedman-MoracoDepartment of Medicine, Emory University, Atlanta GA, USA.
Peter StockDepartment of Surgery, University of California San Francisco, San Francisco CA, USA.
Alexander GilbertDepartment of Surgery, Georgetown University, Washington DC, USA.
Shikha MehtaDepartment of Surgery, University of Alabama Birmingham, Birmingham AL, USA.
Valentina StosorDepartment of Surgery, Northwestern University, Chicago IL, USA.ORCID 0000-0002-0388-5460
Marcus R PereiraDepartment of Medicine, Columbia University, New York NY, USA.
Michele I MorrisDepartment of Medicine, University of Miami, Miami FL, USA.ORCID 0000-0002-4479-8726
Jonathan HandDepartment of Surgery, Ochsner Medical Center, New Orleans LA, USA.
Ghady HaidarDepartment of Medicine, University of Pittsburgh, Pittsburgh PA, USA.
Maricar MalinisDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Carlos A Q SantosDepartment of Internal Medicine, Rush University, Chicago IL, USA.
Joanna SchaenmanDepartment of Surgery, University of California Los Angeles, Los Angeles CA, US.ORCID 0000-0003-1174-3961
Emily A BlumbergDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA, USA.ORCID 0000-0002-5193-6170
David WojciechowskiDepartment of Medicine, UT Southwestern Medical Center.
Jonah OdimTransplantation Branch, NIAID, NIH, Bethesda MD, USA.
Allan MassieDepartment of Surgery, New York University, New York City, New York, USA.
Miruthula Tamil SelvanDepartment of Pathology, Johns Hopkins University, Baltimore MD, USA.
Serena BagnascoDepartment of Pathology, Johns Hopkins University, Baltimore MD, USA.
Dorry SegevDepartment of Surgery, New York University, New York City, New York, USA.
Aaron Ar TobianDepartment of Pathology, Johns Hopkins University, Baltimore MD, USA.
Elmi MullerDepartment of Surgery, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4891-5296
Christine M DurandDepartment of Medicine, Johns Hopkins University, Baltimore MD, USA.ORCID 0000-0003-2605-9257
Andrew D ReddDepartment of Medicine, Johns Hopkins University, Baltimore MD, USA.

Funding

HOPE in Action: A clinical trial of HIV-to-HIV deceased donor kidney transplantationU01AI134591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE, SEGEV, DORRY L. · 2017 to 2021
$11.0M
Kidney Transplantation from Donors with HIV: Impact on Rejection and Long-term OutcomesU01AI177211 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2023 to 2026
$6.9M
T-cell depletion and maintenance of the HIV-1 latent reservoir in distinct tissue compartmentsR01DK131926 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Melissa Laird Smith, AARON A TOBIAN · 2022 to 2026
$3.6M
Maximizing the success of HIV+ to HIV+ kidney transplantation in South AfricaU01AI152153 · NIAID · UNIVERSITY OF CAPE TOWN · PI MULLER, ELMI · 2020 to 2024
$900k
NIAID NIH HHS U01 AI134591NIAID NIH HHS U01 AI152153NIAID NIH HHS U01 AI177211NIDDK NIH HHS R01 DK131926
6 · The paper itself

Abstract

Importance: Lower kidney allograft survival has been demonstrated in kidney transplant recipients (KTR) without HIV whose donors have two apolipoprotein L1 ( Objective: To determine whether Design: Comparative analysis of kidney allograft outcomes in two of the largest longitudinal clinical studies examining transplantation outcomes in PWH. Setting and participants: Two cohorts of HIV-positive KTR (R+) and their respective HIV-negative (D-) or HIV-positive (D+) kidney donors from the South African (SA) HIV+ to HIV+ transplantation clinical study and the United States of America (US) HOPE in Action Kidney transplantation clinical trial. All patients with genomic DNA available for Main outcomes measured: Time to first rejection, HIV-associated nephropathy, graft failure or death were compared by both donor and recipient Results: Genomic DNA was available for 21 donors with HIV and 38 HIV D+/R+ recipients in the SA cohort, and 57 donors (40 D+ and 17 D-) and 119 recipients (49 HIV D+/R+ and 70 D-/R+) in the US cohort. Recipient outcomes were not associated with recipient Conclusions and relevance: In two independent studies, the presence of one

Identifiers

PMID40321250
PMCPMC12047941

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.