Evidence map›Paper›PMID 40321244›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Impairment of endothelial MerTK accelerates atherosclerosis development.

Shijie Liu, Jingke Yao, Hongye Huang, Jinzi Wu, Oishani Banerjee, Bingzhong Xue, Hang Shi, Zufeng Ding

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shijie LiuDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Jingke YaoDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Hongye HuangDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Jinzi WuDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Oishani BanerjeeDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Bingzhong XueDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Hang ShiDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Zufeng DingDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.ORCID 0000-0001-8643-7059

Funding

Impact of hemodynamics on efferocytosis in endothelial cellsR01HL162958 · NHLBI · UNIV OF ARKANSAS FOR MED SCIS · PI Zufeng Ding · 2022 to 2026
$1.7M
NHLBI NIH HHS R01 HL162958
6 · The paper itself

Abstract

Objective: Atherosclerosis is a chronic inflammatory disease primarily affecting large arteries and is the leading cause of cardiovascular disease. MER proto-oncogene tyrosine kinase (MerTK) plays a key role in regulating efferocytosis, a process for the clearance of apoptotic cells. This study investigates the specific contribution of endothelial MerTK to atherosclerosis development. Approach and Results: Big data analytics, human microarray analyses, proteomics, and a unique mouse model with MerTK deficiency in endothelial cells ( Conclusions: Our findings provide strong evidence that endothelial MerTK impairment serves as a novel mechanism in promoting atherosclerosis development.

Indexed as

Atherosclerosisbig data analyticsendothelial cellsMerTKproteomics

Identifiers

PMID40321244
PMCPMC12047952

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.