Evidence map›Paper›PMID 40321210›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular insights into early malignant transition of hepatocellular carcinoma.

Zhengtao Zhang, Hong Li, Lingli Chen, Tao Lu, Xinyi Shentu, Yuanhua Liu, Shuyi Ji, Zhixin Qiu, Yining Zou, Hong Wen and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Zhengtao ZhangState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, P. R. China.
Hong LiShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, P. R. China.
Lingli ChenDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Tao LuDepartment of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200438, P. R. China.
Xinyi ShentuSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, P. R. China.
Yuanhua LiuState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, P. R. China.
Shuyi JiInstitute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, P. R. China.
Zhixin QiuDepartment of Anesthesiology, Zhongshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, P. R. China.
Yining ZouDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Hong WenDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Jing HanDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Zhengzeng JiangDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Jie FanDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.
Dianfan LiState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, P. R. China.
Agavni MesropianLiver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain.
Roser PinyolLiver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain.
Josep M LlovetLiver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain.
Hui DongDepartment of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200438, P. R. China.
Yuan JiDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
Lijian HuiState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, P. R. China.

Funding

The Role of KLF6 in Hepatic FibrosisR01DK056621 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FRIEDMAN, SCOTT L. · 2000 to 2019
$6.2M
Hepatic stellate cells in NASH fibrosis and HCCR01DK128289 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT L. FRIEDMAN · 2021 to 2026
$2.6M
Determinants of immunotherapy response in NASH-Hepatocellular carcinomaR01CA273932 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JOSEP M LLOVET · 2023 to 2026
$2.0M
NCI NIH HHS R01 CA273932NIDDK NIH HHS R01 DK056621NIDDK NIH HHS R01 DK128289
6 · The paper itself

Abstract

The molecular continuum of premalignant-to-malignant transition remains elusive in carcinogenesis, primarily due to the difficulty in sampling transitional lesions. Here, we present comprehensive genomic and immunological profiling of 21 very early hepatocellular carcinomas (veHCCs) arising within 17 cancer-prone DNs. Surprisingly, 82% of cancer-prone DNs harbored

Identifiers

PMID40321210
PMCPMC12047883

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.