Evidence map›Paper›PMID 40321168›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2025

Modelling of the Soft Shell Technique Using Computational Fluid Dynamics.

Ippei Watanabe, Hirokazu Mukuno

Abstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Quantitative assessment of ophthalmic viscosurgical device retention during phacoemulsification and aspiration: an ex vivo analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ippei WatanabeMedical Affairs, Seikagaku Corporation, Chiyoda-ku, Tokyo, Japan.ORCID 0000-0002-7862-5655
Hirokazu MukunoShinnagata Eye Hospital, Kobe, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To clarify how ophthalmic viscosurgical devices (OVDs) behave during the soft shell technique. Methods: We simulated the fluids dynamics of a Dispersive-OVD [Combination of 3% hyaluronic acid (HA) and 4% chondroitin sulfate] and Cohesive-OVD (1% HA with a high molecular weight) during the soft shell technique using the software program Fluent2023R2 and ICEM CFD. During the simulation, 0.1 mL of Dispersive-OVD was injected into the eye model for 9 sec, followed by 0.1 mL of Cohesive-OVD for 5 sec. The mass fraction, static pressure, velocity, shear rate and apparent viscosity of each OVD were evaluated during intraocular injection. Results: Initially, the Dispersive-OVD was injected upward into the anterior chamber. Although the pressure applied to the cannula tip during injection was high, almost no pressure rise occurred inside the eye. Subsequently, injection of Cohesive-OVD pushed the Dispersive-OVD up, forming a thin layer of Dispersive-OVD covering the entire corneal endothelium. Injection of Cohesive-OVD increased the velocity magnitude towards the eye incision; once the OVD filled the eye, it overflowed from the incision. The shear rate of Cohesive-OVD was higher than that of Dispersive-OVD when injected through the cannula lumen and out of the tip. Therefore, the apparent viscosity of Cohesive-OVD near the cannula tip was about one-third lower than that of Dispersive-OVD. The shear rate of the Dispersive-OVD at the corneal endothelial surface during Cohesive-OVD injection was less than 10 Conclusion: Fluid dynamics simulation demonstrated how the soft shell technique works using two agents with different physical properties. The parameters obtained in this study provide useful metrics for understanding and predicting OVD behavior during eye surgery.

Indexed as

cataract surgerychondroitin sulfatehyaluronic acidophthalmic viscosurgical devices

Identifiers

PMID40321168
PMCPMC12048296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.