Evidence map›Paper›PMID 40321160›Full record

ArticleOpen life sciences2025

The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing.

Dagny Lorent, Rafal Nowak, Monika Gazecka, Pawel Zmora, Elzbieta Lenartowicz Onyekaa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dagny LorentDepartment of Molecular Virology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.
Rafal NowakDepartment of Molecular Virology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.
Monika GazeckaDepartment of Molecular Virology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.
Pawel ZmoraDepartment of Molecular Virology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.
Elzbieta Lenartowicz OnyekaaLaboratory of Molecular Diagnostics, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A virus (IAV) is a negative-sense, single-stranded RNA virus, whose genome consists of eight segments encoding multiple structural and non-structural proteins essential for viral replication and host immune evasion. Among these, segment 8 encodes two primary non-structural proteins  NS1, crucial for host immune suppression and virulence and NS2, involved in vRNP export - and their expression is regulated by splicing. Further studies are required to elucidate the role of PKR in IAV mRNA splicing regulation.

Indexed as

double-stranded RNA-activated protein kinaseinfluenza A virusmRNA splicingnon-structural proteins NS1 and NS2pseudoknot structure

Identifiers

PMID40321160
PMCPMC12048893

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.