Evidence map›Paper›PMID 40321144›Full record

ArticleClinical obesity2025

Impact of maternal body mass index (BMI) and gestational weight gain on offspring's weight and BMI z-scores across the first 8 years of life.

Zheng Lu, Iskander L C Shadid, Jhill Shah, Vincent J Carey, Nancy Laranjo, George T O'Connor, Robert S Zeiger, Leonard Bacharier, Augusto A Litonjua, Scott T Weiss and 1 more

Abstract read
In one paragraph

Article in Clinical obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zheng LuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0009-0005-2647-3011
Iskander L C ShadidChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jhill ShahChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Vincent J CareyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Nancy LaranjoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
George T O'ConnorPulmonary Centre, Department of Medicine, Boston Medical Centre, Boston University, Boston, Massachusetts, USA.
Robert S ZeigerDepartment of Clinical Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California, USA.
Leonard BacharierDivision of Pediatric Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University, St. Louis, Missouri, USA.
Augusto A LitonjuaDivision of Pediatric Pulmonary Medicine, Golisano Children's Hospital at University of Rochester Medical Centre, Rochester, New York, USA.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Hooman MirzakhaniChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2290-4436

Funding

SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6M
Multi-omic approaches to mechanisms of vitamin D, environmental influences, and the microbiome on asthmaUH3OD023268 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2018 to 2022
$13.5M
Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood AsthmaU01HL091528 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2009 to 2013
$10.0M
RANDOMIZED CONTROLLED TRIAL: VDAART CONTINUATION STUDY - DCC - LEADR01HL091528 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2014 to 2018
$9.1M
Integrative Longitudinal Genomics of Maternal Asthma-Preeclampsia Overlap and Risk of Childhood AsthmaK01HL146977 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MIRZAKHANI, HOOMAN · 2020 to 2024
$874k
NHLBI NIH HHS 1 K01HL146977 01A1NHLBI NIH HHS K01 HL146977NHLBI NIH HHS L30 HL129467NHLBI NIH HHS R01 HL091528NHLBI NIH HHS T32 HL007427NHLBI NIH HHS U01 HL091528NHLBI NIH HHS U03 HL091528NIH HHS UH3 OD023268
6 · The paper itself

Abstract

While prior studies have linked maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) to birth weight and early childhood obesity, fewer have examined their joint effect on longitudinal growth trajectories, particularly standardized BMI z-scores through school age. We aimed to examine the relationship between maternal pre-pregnancy BMI, GWG and the trajectory of offspring's early-life weight, BMI z-scores and weight percentiles from birth to age 8. Linear mixed models were employed to assess the association between maternal pre-pregnancy BMI, GWG and children's standardized weight-for-age, BMI and length/height-for-age, adjusting for potential confounders. Data were analysed from 806 mother-child pairs from the Vitamin D Antenatal Asthma Reduction Trial, with children followed longitudinally from birth through 8 years of age. Our study demonstrated a significant association between maternal pre-pregnancy BMI and offspring weight-for-age and BMI z-score trajectories (β = .03, 95% confidence interval [CI]: 0.02-0.04 for both; p < .001, respectively). Specifically, children born to mothers with pre-pregnancy BMI of 25-30 kg/m

Indexed as

Body Mass IndexGestational Weight GainMothersPediatric ObesityPrenatal Exposure Delayed EffectsAdultBirth WeightBody WeightChildChild, PreschoolFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleBMI percentileBMI z‐scoreschild's weightgestational weight gainheightmaternal pre‐pregnancy BMI

Identifiers

PMID40321144
PMCPMC12353462

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.