Evidence map›Paper›PMID 40321141›Full record

ArticleHistology and histopathology2025

Luteoloside ameliorates sepsis-induced acute lung injury via AMPK-ULK1 pathway-mediated autophagy.

Bo Xu, Min Huang, Hang Qi, Cheng Liu, Hongzhou Xu, Liang Cai

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Article in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bo XuDepartment of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China. xubodoctor@hotmail.com.
Min HuangDepartment of Infectious Diseases, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Hang QiDepartment of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Cheng LiuICU, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Hongzhou XuDepartment of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Liang CaiDepartment of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.

Funding

2024 Bengbu Science and Technology Guidance Project 2024ZD0017Key Natural Science Fund of Bengbu Medical College 2022byzd039
6 · The paper itself

Abstract

backgroundSeptic patients are at high risk of acute lung injury (ALI). Luteoloside is a flavonoid isolated from natural herbs and has many beneficial effects. This study aimed to investigate the protective role of luteoloside in sepsis-induced ALI.

methodsSepsis was induced by cecal ligation and puncture (CLP) in C57BL/6 mice. Inflammation was induced by lipopolysaccharide (LPS) in MLE-12 cells. The survival rate over 12 days, histological changes in lung and heart, pulmonary edema, vascular leakage, hypoxemia, and inflammation were examined. Apoptosis was detected by TUNEL staining

resultsLuteoloside attenuated lung and cardiac injury, pulmonary edema, vascular leakage, hypoxemia, and inflammation and improved the survival of septic mice. Luteoloside (20 mg/kg) had no toxic effect on the heart, liver, spleen, and kidney in normal mice. Luteoloside enhanced autophagy to inhibit apoptosis

conclusionOverall, luteoloside activates AMPK/ULK1 signaling to stimulate autophagy, thereby inhibiting apoptosis and alleviating sepsis-induced ALI.

Indexed as

Acute Lung InjuryAMP-Activated Protein KinasesAutophagyAutophagy-Related Protein-1 HomologSepsisAnimalsApoptosisCell LineDisease Models, AnimalLungMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinSignal TransductionAMP-Activated Protein KinasesAutophagy-Related Protein-1 HomologNLR Family, Pyrin Domain-Containing 3 ProteinUlk1 protein, mouse

Identifiers

PMID40321141

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.