Evidence map›Paper›PMID 40321105›Full record

Observational studyThe International journal of artificial organs2025

Utility of a water-sparing approach for reducing dialysate flow rates in hospitalized patients with kidney failure.

Amay Parikh, Kirsten Drake, Craig Woda, Cynthia D'Alessandri-Silva, Michael Aragon

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The International journal of artificial organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amay ParikhAdventHealth Health System, Orlando, FL, USA.
Kirsten DrakeTexas Health Harris Methodist Hospital Fort Worth, Fort Worth, TX, USA.
Craig WodaBoston Children's Hospital, Boston, MA, USA.
Cynthia D'Alessandri-SilvaOutset Medical, Inc., San Jose, CA, USA.
Michael AragonOutset Medical, Inc., San Jose, CA, USA.ORCID 0000-0003-0039-3046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHemodialysis (HD) represents a necessary medical intervention for patients with end stage kidney disease (ESKD) with a high carbon footprint that significantly consumes natural resources (i.e. water). Reduction of dialysate flow rate is one strategy that directly targets water waste during HD.

methodsA retrospective multicenter, observational study was conducted over 12 months in patients with AKI-D and ESKD to evaluate treatments with mid-range dialysate flow rates set at Qd 300 mL/min (Green HD) using the Tablo

resultsOne thousand one hundred ninety-five treatments were performed in 433 patients using Green HD (Qd = 300 mL/min,

conclusionThese findings support that higher dialysate flow rates using Conventional systems yield minimal if any benefit in small solute clearance compared to mid-range flow rates. Green HD using the Tablo

Indexed as

Acute Kidney InjuryDialysis SolutionsHemodialysis SolutionsKidney Failure, ChronicRenal DialysisAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeDialysis SolutionsHemodialysis Solutionsdialysate flow rateESKDHemodialysissolute controlTablo Hemodialysis Systemwater conservation

Identifiers

PMID40321105
PMCPMC12152276

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.