Evidence map›Paper›PMID 40321096›Full record

ArticleExperimental physiology2026

Circumferential strain and strain rates of the descending aorta as novel measures of aortic stiffness and wall mechanics from standard cardiac MRI.

Denis J Wakeham, Sauyeh K Zamani, Andrew P Oneglia, Matthew M Howrey, Samer Majeed, Tiffany L Brazile, Joshua A Beckman, James P MacNamara, Mark J Haykowsky, Vlad G Zaha and 4 more

Abstract read
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Soft, Flexible, and Stretchable Platforms for Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Denis J WakehamUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
Sauyeh K ZamaniDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA.ORCID 0000-0003-1484-5226
Andrew P OnegliaDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA.
Matthew M HowreyInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas, USA.
Samer MajeedInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas, USA.
Tiffany L BrazileUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-8215-2144
Joshua A BeckmanUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
James P MacNamaraUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
Mark J HaykowskyFaculty of Nursing, University of Alberta, Edmonton, Canada.
Vlad G ZahaUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
Benjamin D LevineUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-9064-7251
Christopher M HearonUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
Satyam SarmaUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
Michael D NelsonUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-3232-8639

Funding

Targeting skeletal muscle to improve exercise capacity in heart failure with preserved ejection fraction.P01HL137630 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BABB, TONY G · 2019 to 2023
$11.4M
Training in Cardiovascular ResearchT32HL125247 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI JOSEPH A HILL · 2015 to 2026
$4.3M
Mechanism and Modulation of Sex Differences in Myocardial Steatosis Induced Left Ventricular DysfunctionR01HL136601 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NELSON, MICHAEL DOUGLAS · 2018 to 2022
$3.3M
Sympathetic neural patterns and transduction in obesity-associated hypertensionK99HL153777 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HEARON, CHRISTOPHER M · 2020 to 2021
$269k
Retrospective Single Image Multi-endPoint anaLysis (SIMPL) to define pathophysiologic mechanisms of heart failure with preserved ejection fraction.R21HL167171 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NELSON, MICHAEL DOUGLAS · 2023 to 2024
$248k
American Heart Association (AHA) 23POST1022536American Heart Association (AHA) AHA PRE835833HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K99HL153777HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL137630HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL136601HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R21HL167171NHLBI NIH HHS K99 HL153777NHLBI NIH HHS P01 HL137630NHLBI NIH HHS R01 HL136601NHLBI NIH HHS R21 HL167171NHLBI NIH HHS T32 HL125247
6 · The paper itself

Abstract

During standard cardiovascular magnetic resonance (CMR) the horizontal long-axis cine image (i.e., 4-chamber) is captured which includes a cross-section of the descending aorta. The aortic cross-section can be used to assess aortic stiffness (distensibility; ∆area/pressure) or circumferential strain (percentage vascular deformation). We examined whether descending aortic strain from traditional CMR is sensitive to age- and disease-related (heart failure with preserved ejection fraction; HFpEF) arteriosclerosis. We recruited 83 participants into three groups: (1) 34 young individuals (age: 22 ± 3 years; body mass index (BMI): 24.3 ± 2.8 kg/m

Indexed as

Aorta, ThoracicVascular StiffnessAdultAgedFemaleHeart FailureHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleMiddle AgedStroke VolumeYoung Adultageingaortaarterial stiffnessHFpEFmagnetic resonance imaging

Identifiers

PMID40321096
PMCPMC12756861

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.