ReviewExperimental physiology2025
Protein-based perioperative nutrition interventions for improving muscle mass and functional outcomes following orthopaedic surgery.
Review in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- High-Intensity Resistance Training Enhances Strength, But Not Muscle Mass and Physical Functioning Gains during Total Knee Arthroplasty Rehabilitation.Medicine and science in sports and exercise · 2026Trial
- Machine learning prediction model for early postoperative hypoalbuminemia after pulmonary surgery: a retrospective case-matched comparative study.Journal of thoracic disease · 2026Article
- Peri-operative nutrition in femoral neck fracture arthroplasty: a pragmatic framework to mitigate dual-hit catabolism and improve outcomes.Orthopedic reviews · 2026Article
- Indications and Adverse Events of Toradol: Based on FDA Adverse Event Reporting System (FAERS).Pain research & management · 2026Article
- Protein-based perioperative nutrition interventions for improving muscle mass and functional outcomes following orthopaedic surgery.Experimental physiology · 2025Review
- More meat on the bone: Perioperative nutrition and elective orthopaedic surgery.Experimental physiology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
This narrative review provides an overview of protein-based perioperative nutrition interventions for improving muscle mass and functional outcomes in patients undergoing orthopaedic surgery. Globally, the number of joint replacement procedures continues to rise annually, with beneficial outcomes in terms of pain relief and quality of life. However, orthopaedic surgery is associated with a transient decline in skeletal muscle mass, strength and function, with resulting impact on balance and posture, mobility and an increased risk of falls during the perioperative period. Perioperative nutrition interventions targeted at mitigating muscle atrophy, strength loss and reduced function in response to orthopaedic surgery have primarily focused on essential amino acid and protein supplementation. Promising results have been observed in patients undergoing total knee arthroplasty, total hip replacement, surgical treatment of hip fracture and anterior cruciate ligament reconstruction. Preliminary evidence also suggests a role for perioperative β-hydroxy-β-methylbutyrate supplementation in improving muscle mass and function outcomes following orthopaedic surgery. However, translation of findings from experimental studies into clinical practice is required.
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Registered trials
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