ArticleBrain and behavior2025
Differential Expression of LncRNA MIAT and Its Clinical Significance in Intracranial Aneurysms.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntracranial aneurysm (IA) is characterized by localized dilation or ballooning of a blood vessel in the brain with life-threatening consequences. This study set out to investigate the value of Long noncoding RNA myocardial infarction associated transcript (LncRNA MIAT) in diagnosis, rupture prediction, and prognosis for IA patients.
methodsThe clinical characteristics of controls (100 cases) and IA patients, including 88 cases of ruptured IA (RIA) and 132 cases of unruptured IA (UIA), were analyzed using the chi-square test and t-test. MIAT expression in the serum was detected. The diagnostic efficacy of MIAT for IA was assessed through receiver operating characteristic (ROC) curve analysis. IA patients were categorized into low-expression and high-expression groups, and the correlation between MIAT expression and clinical indicators in IA patients was analyzed. The risk factors for IA rupture were analyzed. The correlation between MIAT expression and the overall survival of IA patients was assayed. The risk factors for poor prognosis in IA patients were analyzed.
resultsLncRNA MIAT was elevated in IA patients, with higher expression in RIA patients than in UIA patients. MIAT expression could distinguish between healthy control and IA patients (area under the curve, AUC = 0.794, cut-off value = 1.26, sensitivity = 68.64%, specificity = 83.00%, p < 0.001), healthy control and UIA patients (AUC = 0.782, cut-off value = 1.15, sensitivity = 75.76%, specificity = 68.00%, p < 0.001), and UIA patients and RIA patients (AUC = 0.690, cut-off value = 1.46, sensitivity = 76.14%, specificity = 68.94%, p < 0.001). MIAT expression was significantly associated with hypertension, IA location, and IA rupture status. MIAT was an independent risk factor for IA rupture. For every one-unit increase in the relative expression of MIAT, the risk of poor prognosis in IA patients increased by 2.415 times (p = 0.014, 95% CI: 1.192-4.890). MIAT expression was correlated with the overall survival of IA patients and IA rupture in UIA patients. MIAT was an independent risk factor for poor prognosis of IA patients. For every one-unit increase in the relative expression of MIAT, the risk of poor prognosis in IA patients increased by 2.415 times (p = 0.014, 95% CI: 1.192-4.890).
conclusionHighly expressed MIAT is an independent risk factor for poor prognosis of IA and can support IA diagnosis and rupture prediction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.