ArticleExperimental physiology2025
TREM2
Article in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The TREM2 paradox in fibrosis: a unified mechanism for opposite outcomes across organs.Frontiers in immunology · 2026Review
- TREM2Experimental physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non-invasive biomarkers for this disease. Single-cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster analysis for macrophages was conducted. Blood samples were collected from 38 children with IgAN to measure soluble TREM2 (sTREM2) and soluble CD163 (sCD163) levels and analyse their clinical significance. Single-cell RNA sequencing identified distinct cell clusters in both parenchymal and stromal compartments. Mesangial components were classified into vascular smooth muscle cells/pericytes, mesangial cells, fibroblasts and activated myofibroblasts. Patients with IgAN had a marked increase in myofibroblasts and immune cells in comparison to the control group. Remarkable infiltration of macrophages was observed in the kidneys of IgAN patients, and a subgroup of marcophages with high TREM2 expression was enriched. Children with IgAN exhibited significantly higher plasma sTREM2 levels than healthy individuals, and the sTREM2 level was correlated with sCD163 abundance. Importantly, an increased sTREM2 level was positively associated with the severity of proteinuria. Moreover, the elevation of sTREM2 was correlated with a more advanced pathological grading. In summary, we unveiled a remarkable remodelling of the stromal cellular landscape in childhood IgAN, and TREM2
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.