ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Evaluating In Vivo Penetration of Yeast Rice Ferment Filtrate Into Skin Using Confocal Raman Microspectroscopy: A Pilot Study.
Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Evaluating the Efficacy of Sunscreen Formulas in Reducing UV Filter Permeation Into the Stratum Corneum via In Vivo Confocal Raman Spectroscopy: Insights and Applications for Practical Suncare Product Design.Photodermatology, photoimmunology & photomedicine · 2026Article
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3 authors.
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Abstract
backgroundInvestigating the skin penetration behavior of pharmaceuticals and cosmetics is crucial. Due to the Raman-active properties of many active ingredients, Confocal Raman microspectroscopy (CRM) emerges as a promising, non-invasive technique for penetration studies.
aimTo evaluate the in vivo penetration behavior of yeast rice ferment filtrate (RFF) into the skin using CRM.
methodsRaman spectra of RFF were acquired at 0.5, 1, 2, and 4 h post-application using CRM. The penetration of RFF at various skin depths (10-40 µm) and different time points was analyzed. Multivariate analysis was applied to generate Raman spectral maps that can show RFF depth penetration and spatial distribution across different skin layers.
resultsRFF surpassed the stratum corneum barrier within 30 min and penetrated into the dermis layer after 4 h of application, indicating rapid permeation kinetics. Quantitative analysis, based on Raman spectra, showed increasing RFF penetration over time, reaching 1.02%, 3.17%, 5.29%, and 8.75% after 0.5, 1, 2, and 4 h, respectively. The heat map visualized depth penetration and spatial distribution, indicating a significant increase in penetration with extended application durations.
conclusionCRM proves to be a powerful tool for studying the in vivo penetration of RFF into the skin, offering valuable insights into the complex dynamics underlying its permeation behavior.
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