ArticleBrain and behavior2025
Insomnia Associated With Increased Risk of Atopic Dermatitis: A Two-Sample Mendelian Randomization Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Sleep Disturbance and Atopic Dermatitis: A Bidirectional Relationship With Clinical and Therapeutic Implications.Cureus · 2026Review
- Mendelian randomization studies in atopic dermatitis: causal insights across omics layers.Frontiers in immunology · 2026Review
- Integrated Retrospective and Post-GWAS Analyses Reveal Mechanisms Linking Nightly Short Sleep to Asthma.Brain and behavior · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundThe causal relationships between sleep traits and allergic diseases remain unclear. This study sought to explore their causal associations using Mendelian randomization (MR) analysis.
methodsThis study utilized summary-level data from genome-wide association studies (GWAS) and selected genetic variants associated with sleep traits as instrumental variables (IVs). For the primary analysis, the inverse-variance weighted (IVW) method was utilized. To further evaluate causal effects, we applied weighted median, weighted mode, and MR-Egger regression. Sensitivity analyses, such as linkage disequilibrium score (LDSC) regression, MR-Egger regression, Cochran's Q test, leave-one-out analysis, and MR-PRESSO, were carried out to confirm result robustness.
resultsIVW analysis revealed that genetically predicted insomnia was causally associated with a higher risk of atopic dermatitis (OR = 1.79, 95% CI: 1.17-2.74, P = 0.01), and preferring an evening chronotype was causally associated with a lower risk of allergic rhinitis (IVW: OR = 0.99, 95% CI: 0.99-1.00, P = 0.02). The LDSC analysis further identified a significant genetic correlation between insomnia and atopic dermatitis (r
conclusionChronotype and insomnia were causally associated with the efficacy of sleep-based interventions in allergic disease management.
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