ArticleActa paediatrica (Oslo, Norway : 1992)2025
Oxygenation Instability and Short-Term Morbidities Among Very-Low-Birthweight Premature Infants.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimOxygenation instability is common among very-low-birthweight premature infants (VLBW) and is correlated with morbidities of prematurity. We aimed to study the association of oxygenation instability of VLBW premature infants during the first week of life, as documented by the SpO
methodsVLBW infants requiring respiratory support were included. 24-h SpO
resultsSeventy-seven infants with mean (SD) gestational age-28.5 (2.1) weeks and birth weight-1040 (243) g were included in our study. 2063 histograms were recorded. Mean (SD) length of follow-up-27.5 (20.1) days per infant. 62% of infants remained stable during the follow-up period, while 38% experienced instability. 52% entered the unstable period during the first week of life. These infants had a higher risk of bronchopulmonary dysplasia (BPD)/death after adjusting for gestational age (OR [95% CI] 17.5 [4.0, 77.2]; p < 0.001), and for a variety of demographic and clinical variables (OR [95% CI] 32.4 [2.5, 418.5]; p = 0.008).
conclusionVLBW premature infants demonstrate a distinct instability pattern. Entry into the unstable phase during the first week of life is associated with BPD/death, making it a potential predictive tool. Hypoxemia burden during the first week of life is correlated with BPD or death, while iatrogenic hyperoxemia is not.
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