Evidence map›Paper›PMID 40320687›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2025

Acute retinal necrosis associated with dimethyl fumarate.

Christopher Paisey, Karen Curtin, Simon J Epps, Claire M Rice

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christopher PaiseySouthmead Hospital, North Bristol NHS Trust, Bristol, UK.
Karen CurtinBristol Eye Hospital, University Hospitals of Bristol and Weston NHS Foundation Trust, Bristol, UK.
Simon J EppsBristol Eye Hospital, University Hospitals of Bristol and Weston NHS Foundation Trust, Bristol, UK.
Claire M RiceSouthmead Hospital, North Bristol NHS Trust, Bristol, UK; Translational Health Sciences, University of Bristol, Bristol, UK.ORCID 0000-0002-9851-4426

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe full range of side effects of disease-modifying treatment for multiple sclerosis (MS) remains to be determined. To date, four serious varicella zoster virus (VZV) infections have been reported in association with dimethyl fumarate (DMF). REPORT: A 44-year-old man on DMF for relapsing remitting MS presented with monocular pain and visual impairment. Ophthalmological examination revealed panuveitis with arteritis, retinitis and vitritis. Vitreous PCR was positive for VZV confirming the clinical impression of acute retinal necrosis (ARN). DISCUSSION: ARN due to VZV may mimic optic neuritis in people on disease-modifying therapy for MS.

Indexed as

Dimethyl FumarateImmunosuppressive AgentsMultiple Sclerosis, Relapsing-RemittingRetinal Necrosis Syndrome, AcuteAdultHerpesvirus 3, HumanHumansMaleDimethyl FumarateImmunosuppressive Agentsacute retinal necrosisDimethyl fumarateoptic neuritisrelapsing remitting multiple sclerosisvaricella zoster virus

Identifiers

PMID40320687
PMCPMC12547032

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.