Evidence map›Paper›PMID 40320590›Full record

ArticleBritish journal of haematology2025

Cholesterol-conjugated miR-29b induces fetal haemoglobin expression via γ-globin promoter demethylation in the Townes mouse model for sickle cell anaemia.

Chithra D Palani, Alana Smith, Xueyuan Cao, Biaoru Li, Betty S Pace, Athena Starlard-Davenport

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chithra D PalaniDivision of Hematology/Oncology, Department of Pediatrics, Augusta University, Augusta, Georgia, USA.
Alana SmithDepartment of Genetics, Genomics and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Xueyuan CaoDepartment of Health Promotion and Disease Prevention, College of Nursing, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Biaoru LiDivision of Hematology/Oncology, Department of Pediatrics, Augusta University, Augusta, Georgia, USA.
Betty S PaceDivision of Hematology/Oncology, Department of Pediatrics, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0002-1275-4112
Athena Starlard-DavenportDepartment of Genetics, Genomics and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-8938-237X

Funding

MicroRNA-based epigenetic approach to induce fetal hemoglobinR01HL144641 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI STARLARD-DAVENPORT, ATHENA · 2020 to 2022
$928k
NHLBI NIH HHS R01 HL144641NIH HHS R01HL144641
6 · The paper itself

Abstract

Cholesterol-conjugated miRNA has emerged as a viable system for preventing small molecule degradation in plasma with low toxicity and high delivery efficiency. We previously established that miR-29b induces fetal haemoglobin (HbF) in Townes sickle cell anaemia (SCA) mice using a continuous infusion mini-osmotic pump. Herein, we expanded the scope of our work to determine the ability of intermittent subcutaneous cholesterol-conjugated miR-29b (Chol-miR-29b) to induce HbF expression in SCA mice. Blood was collected for automated complete blood counts with differential, reticulocyte count and γ-globin and β

Indexed as

Anemia, Sickle CellCholesterolFetal Hemoglobingamma-GlobinsMicroRNAsPromoter Regions, GeneticAnimalsDemethylationDisease Models, AnimalDNA MethylationGene Expression RegulationMiceCholesterolFetal Hemoglobingamma-GlobinsMicroRNAsMIRN29 microRNA, mouseDNMT3hypomethylationmiR‐29bsickle cell anaemiaγ‐globin

Identifiers

PMID40320590
PMCPMC12167133

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.