CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density.

Sajad Monjezi, Vahid Soleimani, Maryam Cheraghzadeh, Saeed Ghanbari, Maryam Adelipour

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Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Sajad MonjeziDepartment of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Vahid SoleimaniDepartment of Pathology, School of Medicine, Cancer Institute, Tehran University of Medical Science, Tehran, Iran.

Maryam CheraghzadehDepartment of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Saeed GhanbariDepartment of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Maryam AdelipourDepartment of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. adelimaryam@rocketmail.com.

Funding

Ahvaz Jundishapur University of Medical Sciences CMRC-0050

6 · The paper itself

Abstract

objectiveBased on the available evidence, the cold-inducible RNA-binding protein (CIRBP) appears to play a role in increasing the stability of hypoxia-inducible factor 1-alpha (HIF1α) mRNA. This research aimed to examine the levels of CIRBP and HIF1α mRNA within breast tumor tissues and explore the relationship between their gene expression and tumor Microvascular density (MVD).

resultsThe results revealed a significant upregulation of CIRBP (5.07-fold) and HIF1α (4.5-fold) gene expression in BC samples compared to the surrounding normal tissues (p < 0.001). This upregulation was also associated with various clinicopathologic features. Furthermore, there was a correlation between CIRBP mRNA expression, HIF1α mRNA expression, and MVD. Consequently, this study suggests that CIRBP may have a role in promoting angiogenesis in BC.

Indexed as

Breast NeoplasmsGene Expression Regulation, NeoplasticHypoxia-Inducible Factor 1, alpha SubunitMicrovascular DensityNeovascularization, PathologicRNA-Binding ProteinsRNA, MessengerAdultAgedFemaleHumansMiddle AgedCIRBP protein, humanHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitRNA-Binding ProteinsRNA, MessengerBreast cancerGene expressionMicrovascular density

Identifiers

PMID40320538

DOI10.1186/s13104-025-07265-5

PMCPMC12049796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.