Evidence map›Paper›PMID 40320485›Full record

ArticleAnnals of hematology2025

The role of the immune system in progressive multifocal leukoencephalopathy: a comparative analysis of two cases following autologous and allogeneic hematopoietic stem cell transplantation.

Biancamaria Mandelli, Roberta Mazzarella, Andrea Corbingi, Elettra Ortu La Barbera, Salvatore Perrone, David Fanciullo, Martina Lorenzon, Giada Pacitto, Natalia Cenfra, Sergio Mecarocci and 2 more

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In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Biancamaria Mandelli *Hematology, Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy. biancamaria.mandelli@uniroma1.it.
Roberta Mazzarella *Hematology, Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy.
Andrea CorbingiDepartment of Hematology, Polo Universitario Pontino, S.M. Goretti Hospital, Latina, Italy. andreacorbingi@gmail.com.
Elettra Ortu La BarberaDepartment of Hematology, Polo Universitario Pontino, S.M. Goretti Hospital, Latina, Italy.
Salvatore PerroneDepartment of Hematology, Polo Universitario Pontino, S.M. Goretti Hospital, Latina, Italy.
David FanciulloHematology, Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy.
Martina LorenzonHematology, Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy.
Giada PacittoHematology, Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy.
Natalia CenfraDepartment of Hematology, Polo Universitario Pontino, S.M. Goretti Hospital, Latina, Italy.
Sergio MecarocciDepartment of Hematology, Polo Universitario Pontino, S.M. Goretti Hospital, Latina, Italy.
Sofia AsioliDepartment of Biomedical and Neuromotor Sciences (DIBINEM)-Surgical Pathology Section, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Alessandro PulsoniDepartment of Hematology, Polo Universitario Pontino, S.M. Goretti Hospital, Latina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare, subacute demyelinating disorder of the central nervous system (CNS) caused by the JCV. In immunosuppressed hosts, PML is caused by reactivation of a latent infection rather than primary exposure. Hematological patients, particularly post-transplant, presenting with worsening neurological symptoms should promptly consider PML in the differential diagnosis. The rarity of PML after autologous or allogeneic hematopoietic stem cell transplantation (HSCT) and the absence of a universally effective therapy represents a clinical challenge. Here, we present two cases of PML developed after autologous and allogeneic HSCT, with completely different outcomes dependent on the patients' clinical backgrounds and the level of immune system competence which is the key factor in determining either the onset or viral clearance of the infection.

Indexed as

Hematopoietic Stem Cell TransplantationImmune SystemLeukoencephalopathy, Progressive MultifocalAdultFemaleHumansImmunocompromised HostJC VirusMaleMiddle AgedTransplantation, AutologousTransplantation, HomologousAcute myeloid leukemiaBone marrow transplantationDiffuse large B cell lymphomaProgressive Multifocal Leucoencephalopathy

Identifiers

PMID40320485
PMCPMC12283870

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.