Evidence map›Paper›PMID 40320480›Full record

ArticleExperimental brain research2025

Effects of stepping practice and functional electrical stmulation on neuromotor excitability in able bodied young adults.

Jacob Spencer, Fisayo K Aloba, Alexandra Slusarenko, Taylor Leone, Jay Patel, Lily Eyvazzadeh, Anna-Lee Lynch, Michael R Borich, Trisha M Kesar

Abstract read
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In one paragraph

Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacob SpencerDivision of Physical Therapy, Department of Rehabilitation Medicine, Emory University, Atlanta, GA, USA.
Fisayo K AlobaDivision of Physical Therapy, Department of Rehabilitation Medicine, Emory University, Atlanta, GA, USA.
Alexandra SlusarenkoDivision of Physical Therapy, Department of Rehabilitation Medicine, Emory University, Atlanta, GA, USA.
Taylor LeoneDivision of Physical Therapy, Department of Rehabilitation Medicine, Emory University, Atlanta, GA, USA.
Jay PatelSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Lily EyvazzadehNeuroscience and Behavioral Biology Undergraduate Program, College of Arts and Sciences, Emory University, Atlanta, GA, USA.
Anna-Lee LynchNeuroscience and Behavioral Biology Undergraduate Program, College of Arts and Sciences, Emory University, Atlanta, GA, USA.
Michael R BorichDivision of Physical Therapy, Department of Rehabilitation Medicine, Emory University, Atlanta, GA, USA.
Trisha M KesarDivision of Physical Therapy, Department of Rehabilitation Medicine, Emory University, Atlanta, GA, USA. trisha.m.kesar@emory.edu.

Funding

Biomechanical and neural mechanisms of post-stroke gait trainingR01HD095975 · NICHD · EMORY UNIVERSITY · PI KESAR, TRISHA · 2019 to 2024
$2.9M
Neurophysiologic correlates of training-induced locomotor learning post-strokeF31HD108988 · NICHD · EMORY UNIVERSITY · PI SPENCER, JACOB · 2022 to 2024
$142k
NICHD NIH HHS F31 HD108988NICHD NIH HHS R01 HD095975
6 · The paper itself

Abstract

The neural processes underlying gait retraining interventions that combine stepping practice with electrical stimulation are poorly understood. The purpose of this study was to compare acute changes in corticomotor excitability measured by motor evoked potential (MEP) amplitude, monosynaptic stretch reflex excitability measured by H/M ratio, and propulsive force generation during gait measured by anterior ground reaction forces (AGRF), induced by 30-minutes of fast walking (Fast) and 30-minutes of fast walking with functional electrical stimulation of the ankle plantarflexors and dorsiflexors (FastFES) in 14 able-bodied young adults. Our results showed that FastFES, but not Fast elicited a significant acute decrease in tibialis anterior MEP amplitude (p = .01). Furthermore, the practice-induced acute decrease in tibialis anterior MEP amplitudes was significantly larger for FastFES than Fast (p = .04). FastFES also elicited a statistically significant increase in the AGRF in the tested limb (p = .01), which was significantly larger than the change induced by Fast (p = .04). Additionally, baseline soleus MEP amplitude was positively correlated with within-session change in AGRF (p = .04, r

Indexed as

Evoked Potentials, MotorGaitMotor CortexMuscle, SkeletalPractice, PsychologicalReflex, StretchWalkingAdultElectric StimulationElectromyographyFemaleHumansMaleYoung AdultCorticospinal tractFunctional electrical stimulationGait trainingNeuroplasticityWalking exercise

Identifiers

PMID40320480

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.