Evidence map›Paper›PMID 40320453›Full record

Trial reportExperimental brain research2025

Testing the effectiveness of combined attention modification training with right dorso-lateral prefrontal cortex theta-burst stimulation on reducing levels of anxiety and attentional bias.

Maria Sikki, Katerina Konikkou, Nikos Kostantinou, Kostas A Fanti

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maria SikkiUniversity of Cyprus, Nicosia, Cyprus.
Katerina KonikkouUniversity of Cyprus, Nicosia, Cyprus.
Nikos KostantinouCyprus University of Technology, Nicosia, Cyprus.
Kostas A FantiUniversity of Cyprus, Nicosia, Cyprus. kfanti@ucy.ac.cy.ORCID http://orcid.org/0000-0002-3484-7483

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurostimulation techniques, such as continuous theta-burst stimulation (cTBS), over the dorsolateral prefrontal cortex (DLPFC) have been associated with improvements in anxiety symptoms and emotion processing. The aim of this feasibility study was the evaluation of the effectiveness of cTBS over the right DLPFC combined with Attention Modification Training (AMT) on reducing levels of anxiety and attentional bias. A 40s-cTBS session (real or sham) over the right DLPFC was administrated at 8 treatment sessions over a 2-week period, and each cTBS treatment was followed by computer-based AMT (real or control). Eighty-nine participants (Mage = 21.29, SD = 2.06, 50.56% females) differentiated on levels of anxiety were randomly assigned to the following treatment groups (i) cTBS and AMT, (ii) cTBS and control AMT, and (iii) sham cTBS and AMT. Findings suggested that cTBS combined with AMT treatment was not superior to sham cTBS and AMT on reducing self-reported anxiety symptoms. However, combined cTBS and AMT was associated with increased attention towards positive stimuli and increased gaze fixation in the mouth region of happy facial expressions. Current results provide promising evidence for the effectiveness of AMT in reducing anxiety symptoms and contribute to existing knowledge on how inhibitory stimulation over the right DLPFC combined with AMT may influence emotion processing. Present findings can inform future treatments designed to address the attention mechanisms leading to anxiety symptoms.

Indexed as

AnxietyAttentionAttentional BiasDorsolateral Prefrontal CortexPrefrontal CortexTheta RhythmTranscranial Magnetic StimulationFacial ExpressionFeasibility StudiesFemaleHumansMaleTreatment OutcomeYoung Adult

Identifiers

PMID40320453
PMCPMC12050235

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.