ArticleThoracic cancer2025
Global, Regional, and National Burden of Breast Cancer, 1990-2021, and Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021.
Article in Thoracic cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A Quick Reverse Transfection and Dual-Imaging Protocol for Simultaneous Viability and Oligonucleotide Delivery Assessment in 4T1 Cells.Methods and protocols · 2026Article
- Nitrogen-doped carbon nanodots-based "off-on" fluorescent sensor for the detection of breast cancer-derived exosomes and early diagnosis.Analytical and bioanalytical chemistry · 2026Article
- Trends in male breast cancer in Spain, 1999-2023: a nationwide analysis of incidence and mortality.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Trends in Female Breast Cancer Incidence among Japanese, Korean, and US Populations: An Age-Period-Cohort Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Prevalence, severity and associated risk factors of symptomatic dry eye among breast cancer patients receiving systemic therapy in Palestine.Scientific reports · 2026Article
- Global burden and trends of breast cancer: GLOBOCAN 2022 estimates of incidence and mortality in 185 countries.Chinese medical journal · 2026Article
- Temporal Trends in Mortality of Female Cancers Among Women and the Impact of COVID-19 in Low- and Middle-Income Countries, 1990-2023: An Age-Period-Cohort Analysis from the Global Burden of Disease Study 2023.International journal of women's health · 2026Article
- The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection.Ecancermedicalscience · 2026Review
- Burden of Breast Cancer and Its Attributable Risk Factors in the Belt and Road Initiative Countries, 1990-2021.Thoracic cancer · 2025Article
- Coping Strategies and Health-Related Quality of Life in Breast Cancer Survivors.European journal of investigation in health, psychology and education · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study analyzes the global burden of breast cancer (BC) over the past 30 years, identifies key risk factors, and projects future incidence and mortality through 2050.
methodsData were sourced from the 2021 Global Burden of Disease (GBD) database. The estimated annual percentage change (EAPC) was used to assess trends, and country development was measured using the Socio-Demographic Index (SDI). Projections were conducted using Bayesian age-period-cohort and autoregressive integrated moving average models.
resultsIn 2021, approximately 2.12 million new breast cancer cases and 674 199 deaths were recorded globally. From 1990 to 2021, incidence and prevalence increased, while mortality and disability-adjusted life years (DALYs) declined overall. Regional and national variations were observed, alongside age and gender differences in the disease burden. A diet high in red meat and a high body mass index were the leading global risk factors for breast cancer deaths. The BC burden was positively correlated with SDI across 21 GBD regions. Decomposition analysis highlighted demographic factors as the main drivers of increased disease burden over the past three decades. Projections indicate that BC incidence will continue to rise through 2050.
conclusionsWhile global BC mortality has decreased over the past 30 years, incidence continues to rise. Low-SDI regions face increasing challenges, as incidence, mortality, and DALYs persistently climb. These findings underscore the need for targeted public health strategies and equitable resource distribution to mitigate the rising burden of breast cancer.
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