Evidence map›Paper›PMID 40320146›Full record

ArticleTransplantation and cellular therapy2025

Out-of-Pocket Expenditures and Financial Hardship Among Patients With Myelodysplastic Syndrome Undergoing Allogeneic Transplant or Hypomethylating Agent / Supportive Care (BMT CTN 1102).

Christopher T Su, Wael Saber, Aasthaa Bansal, Li Li, Ryotaro Nakamura, Corey Cutler, Joshua A Roth, Winona Wright, Lotte Steuten, Scott D Ramsey

Abstract read
In one paragraph

Article in Transplantation and cellular therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christopher T SuFred Hutchinson Cancer Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington. Electronic address: chrissu@uw.edu.
Wael SaberDepartment of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Aasthaa BansalFred Hutchinson Cancer Center, Seattle, Washington.
Li LiFred Hutchinson Cancer Center, Seattle, Washington.
Ryotaro NakamuraHematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Comprehensive Cancer Center, Duarte, California.
Corey CutlerDana-Farber Cancer Institute, Boston, Massachusetts.
Joshua A RothDepartment of Pharmacy, University of Washington, Seattle, Washington; Pfizer Inc., New York, New York.
Winona WrightFred Hutchinson Cancer Center, Seattle, Washington.
Lotte SteutenOffice of Health Economics, London, Great Britain.
Scott D RamseyDepartment of Medicine, University of Washington, Seattle, Washington; Department of Pharmacy, University of Washington, Seattle, Washington.

Funding

Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc.U24HL138660 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Steven M. DeVine, Mehdi Hussain Hamadani · 2017 to 2026
$71.4M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
CAREER DEVELOPMENT IN PEDIATRIC AND MEDICAL ONCOLOGYK12CA076930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DAVIDSON, NANCY ELLEN, MESHINCHI, SOHEIL · 1997 to 2025
$13.1M
City of Hope Core Clinical Center for the Blood and Marrow Transplant Clinical Trials NetworkUG1HL069278 · NHLBI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI RYOTARO NAKAMURA · 2017 to 2026
$2.2M
Cost Effectiveness Analysis of Stem Cell Transplant in Older MDS PatientsR01HL126589 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI RAMSEY, SCOTT D., SABER, WAEL · 2015 to 2018
$1.7M
NCI NIH HHS K12 CA076930NHLBI NIH HHS R01 HL126589NHLBI NIH HHS U10 HL069294NHLBI NIH HHS U24 HL138660NHLBI NIH HHS UG1 HL069278
6 · The paper itself

Abstract

introductionThe Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 1102 trial demonstrated that allogeneic hematopoietic cell transplantation (HCT) was associated with superior overall survival compared to non-HCT approaches among elderly patients with higher-risk myelodysplastic syndrome (MDS). The trial included an ancillary cost diary component to assess the out-of-pocket (OOP) expenditures and financial hardship in the post-HCT period through 3 phased surveys for up to 19 months after enrollment.

objectiveThe purpose of the study is to assess the OOP costs and financial hardship experienced by participants of BMT CTN 1102. STUDY

designBMT CTN 1102 assigned participants to Donor and No-Donor arms based on donor availability. Participants could additionally enroll in the ancillary cost diary component, with a total of 138 participants returning 267 surveys across 3 survey waves at 1-, 7-, and 19-months after enrollment. As participants who underwent HCT returned 78% (207/267) of the total surveys, we report on the collected data descriptively.

resultsParticipants who underwent HCT had high levels of monthly OOP expenditure ($1126, $812, $442) and financial hardship (47%, 53%, 57%) across the 3 survey waves. For reference, participants who did not undergo HCT generally reported lower levels of OOP expenditure ($478, $845, $256) and financial hardship (37%, 55%, 46%).

conclusionAmong BMT CTN 1102 participants, those who underwent HCT reported high levels of OOP expenditures and financial hardship for up to 19 months after enrollment. Ongoing routine assessment of patient-level OOP expenditures and financial burden may be helpful in the post-HCT survivorship period.

Indexed as

Financial StressHealth ExpendituresHematopoietic Stem Cell TransplantationMyelodysplastic SyndromesAdultAgedFemaleHumansMaleMiddle AgedTransplantation, HomologousAllogeneic transplantationcost of illnessfinancial stressmyelodysplastic syndromeSurvivorship

Identifiers

PMID40320146
PMCPMC12229757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.