ArticleJournal of biomedical informatics2025
CD-Tron: Leveraging large clinical language model for early detection of cognitive decline from electronic health records.
Article in Journal of biomedical informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fine-Tuning, Retrieval-Augmented Generation, and Hybrid Adaptation of Language Models for Clinical Decision-Making in Health Care: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Keeping Medical AI Healthy and Trustworthy: A Review of Detection and Correction Methods for System Degradation.IEEE transactions on bio-medical engineering · 2026Review
- The impact of digital infrastructure construction on the depressive symptoms among middle-aged and older adults: evidence from China.BMC public health · 2026Article
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Abstract
backgroundEarly detection of cognitive decline during the preclinical stage of Alzheimer's disease and related dementias (AD/ADRD) is crucial for timely intervention and treatment. Clinical notes in the electronic health record contain valuable information that can aid in the early identification of cognitive decline. In this study, we utilize advanced large clinical language models, fine-tuned on clinical notes, to improve the early detection of cognitive decline.
methodsWe collected clinical notes from 2,166 patients spanning the 4 years preceding their initial mild cognitive impairment (MCI) diagnosis from the Enterprise Data Warehouse of Mass General Brigham. To train the model, we developed CD-Tron, built upon a large clinical language model that was finetuned using 4,949 expert-labeled note sections. For evaluation, the trained model was applied to 1,996 independent note sections to assess its performance on real-world unstructured clinical data. Additionally, we used explainable AI techniques, specifically SHAP values (SHapley Additive exPlanations), to interpret the model's predictions and provide insight into the most influential features. Error analysis was also facilitated to further analyze the model's prediction.
resultsCD-Tron significantly outperforms baseline models, achieving notable improvements in precision, recall, and AUC metrics for detecting cognitive decline (CD). Tested on many real-world clinical notes, CD-Tron demonstrated high sensitivity with only one false negative, crucial for clinical applications prioritizing early and accurate CD detection. SHAP-based interpretability analysis highlighted key textual features contributing to model predictions, supporting transparency and clinician understanding.
conclusionCD-Tron offers a novel approach to early cognitive decline detection by applying large clinical language models to free-text EHR data. Pretrained on real-world clinical notes, it accurately identifies early cognitive decline and integrates SHAP for interpretability, enhancing transparency in predictions.
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Registered trials
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